UDP-N-ACETYLGLUCOSAMINE-1-PHOSPHATE URIDYLTRA
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1hm0(A) : SNFAIILAAGKGTRMKSDLPKVLHKVAGISMLEHVFRSVGAIQPEKTVTV 
         :                                                    
 1hm9(A) : SNFAIILAAGKGTRMKSDLPKVLHKVAGISMLEHVFRSVGAIQPEKTVTV 
           __________________________________________________ 

           __________________________________________________ 
 1hm0(A) : VGHKAELVEEVLAGQTEFVTQSEQLGTGHAVMMTEPILEGLSGHTLVIAG 
         :                                                    
 1hm9(A) : VGHKAELVEEVLAGQTEFVTQSEQLGTGHAVMMTEPILEGLSGHTLVIAG 
           __________________________________________________ 

           _________________________129______________________ 
 1hm0(A) : DTPLITGESLKNLIDFHINHKNVATILTAETDNPFGYGRIV------vLR 
         :                                                    
 1hm9(A) : DTPLITGESLKNLIDFHINHKNVATILTAETDNPFGYGRIVRNDNAEVLR 
           _________________________129______________________ 

           _______________169________________________________ 
 1hm0(A) : IVEQKDATDFEKQIKEINTGTYVFDNERLFEALKNINTNNAQGEYYITDV 
         :                                                    
 1hm9(A) : IVEQKDATDFEKQIKEINTGTYVFDNERLFEALKNINTNNAQGEYYITDV 
           _______________169________________________________ 

           __________________________________________________ 
 1hm0(A) : IGIFRETGEKVGAYTLKDFDESLGVNDRVALATAESVMRRRINHKHMVNG 
         :                                                    
 1hm9(A) : IGIFRETGEKVGAYTLKDFDESLGVNDRVALATAESVMRRRINHKHMVNG 
           __________________________________________________ 

           __________________________________________________ 
 1hm0(A) : VSFVNPEATYIDIDVEIAPEVQIEANVILKGQTKIGAETVLTNGTYVVDS 
         :                                                    
 1hm9(A) : VSFVNPEATYIDIDVEIAPEVQIEANVILKGQTKIGAETVLTNGTYVVDS 
           __________________________________________________ 

           __________________________________________________ 
 1hm0(A) : TIGAGAVITNSMIEESSVADGVTVGPYAHIRPNSSLGAQVHIGNFVEVKG 
         :                                                    
 1hm9(A) : TIGAGAVITNSMIEESSVADGVTVGPYAHIRPNSSLGAQVHIGNFVEVKG 
           __________________________________________________ 

           __________________________________________________ 
 1hm0(A) : SSIGENTKAGHLTYIGNCEVGSNVNFGAGTITVNYDGKNKYKTVIGDNVF 
         :                                                    
 1hm9(A) : SSIGENTKAGHLTYIGNCEVGSNVNFGAGTITVNYDGKNKYKTVIGDNVF 
           __________________________________________________ 

           __________________________________________________ 
 1hm0(A) : VGSNSTIIAPVELGDNSLVGAGSTITKDVPADAIAIGRGRQINKDE**** 
         :                                                    
 1hm9(A) : VGSNSTIIAPVELGDNSLVGAGSTITKDVPADAIAIGRGRQINKDEYATR 
           __________________________________________________ 

           ________                                           
 1hm0(A) : ********                                           
         :                                                    
 1hm9(A) : LPHHPKNQ                                           
           ________                                           

Details

  Property   Value
 Conformer 1 1hm0(A)
 Conformer 2 1hm9(A)
 Radius gyration for conformer 1 30.32 A
 Radius gyration for conformer 2 29.72 A
 EC Number 2.7.7.23  
Click here to see the DynDom results or the famliy
 Trigger ligands UD11500
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact Yes
 Spanning ligands Yes
 Residues in enzyme contacting ligands ALA10  ALA100  ALA81  ALA9  ARG15  ASN169  ASN227  ASP102  GLN72  GLN75  GLU154  GLY101  GLY11  GLY139  GLY225  GLY77  ILE198  LEU76  LEU8  LYS22  THR103  THR170  THR199  THR78  TYR138  TYR197 
 Residues in extended bending regions contacting ligands ASN169  THR170 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands ASN169  THR170 
  Residues in extended bending regions with an H-bond between its main chain and ligands ASN169  THR170 
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT