OROTIDINE 5'-MONOPHOSPHATE DECARBOXYLASE
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           ____16_19_________________________________________ 
 1eix(C) : *VTNSPVVVALDYHNRDDALAFVDKIDPRDCRLKVGKEMFTLFGPQFVRE 
         :                                                    
 1l2u(A) : AVTNSPVVVALDYHNRDDALAFVDKIDPRDCRLKVGKEMFTLFGPQFVRE 
           ____16_19_________________________________________ 

           __________________________________________________ 
 1eix(C) : LQQRGFDIFLDLKFHDIPNTAAHAVAAAADLGVWMVNVHASGGARMMTAA 
         :                                                    
 1l2u(A) : LQQRGFDIFLDLKFHDIPNTAAHAVAAAADLGVWMVNVHASGGARMMTAA 
           __________________________________________________ 

           __________________________________________________ 
 1eix(C) : REALVPFGKDAPLLIAVTVLTSMEASDLVDLGMTLSPADYAERLAALTQK 
         :                                                    
 1l2u(A) : REALVPFGKDAPLLIAVTVLTSMEASDLVDLGMTLSPADYAERLAALTQK 
           __________________________________________________ 

           ________________________187_______________________ 
 1eix(C) : CGLDGVVCSAQEAVRFKQVFGQEFKLVTPGIRPQGSEAGDQRRIMTPEQA 
         :                                                    
 1l2u(A) : CGLDGVVCSAQEAVRFKQVFGQEFKLVTPGIRPQ---------iMTPEQA 
           ________________________187_______________________ 

           ________________________237______                  
 1eix(C) : LSAGVDYMVIGRPVTQSVDPAQTLKAINASLQR                  
         :                                                    
 1l2u(A) : LSAGVDYMVIGRPVTQSVDPAQTLKAINASLQR                  
           ________________________237______                  

Details

  Property   Value
 Conformer 1 1eix(C)
 Conformer 2 1l2u(A)
 Radius gyration for conformer 1 17.01 A
 Radius gyration for conformer 2 17.15 A
 EC Number 4.1.1.23  
Click here to see the DynDom results or the famliy
 Trigger ligands BMQ1303
 Trigger ligands in which conformation Conformation  1
 Conformaton with trigger ligands is compact Yes
 Spanning ligands Yes
 Residues in enzyme contacting ligands ALA20  ARG192  ARG222  ASP22  ASP71  GLN201  GLY221  LEU130  LYS44  LYS73  PRO189  THR131  VAL167  VAL219 
 Residues in extended bending regions contacting ligands ALA20  ASP22  PRO189 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands ASP22 
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT