URIDINE DIPHOSPHO-N-ACETYLENOLPYRUVYLGLUCOSAM
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           ______________________________________________50__ 
 1mbt    : HSLKPWNTFGIDHNAQHIVCAEDEQQLLNAWQYATAEGQPVLILGEGSNV 
         :                                                    
 1uxy    : HSLKPWNTFGIDHNAQHIVCAEDEQQLLNAWQYATAEGQPVLILGEGSNV 
           ______________________________________________50__ 

           54_57_____________________________________________ 
 1mbt    : LFLEDYRGTVIINRIKGIEIHDEPDAWYLHVGAGENWHRLVKYTLQEGMP 
         :                                                    
 1uxy    : LFLEDYRGTVIINRIKGIEIHDEPDAWYLHVGAGENWHRLVKYTLQEGMP 
           54_57_____________________________________________ 

           __________________________________________________ 
 1mbt    : GLENLALIPGCVGSSPIQNIGAYGVELQRVCAYVDSVELATGKQVRLTAK 
         :                                                    
 1uxy    : GLENLALIPGCVGSSPIQNIGAYGVELQRVCAYVDSVELATGKQVRLTAK 
           __________________________________________________ 

           __________________________________________________ 
 1mbt    : ECRFGYRDSIFKHEYQDRFAIVAVGLRLPKEWQPVLTYGDLTRLDPTTVT 
         :                                                    
 1uxy    : ECRFGYRDSIFKHEYQDRFAIVAVGLRLPKEWQPVLTYGDLTRLDPTTVT 
           __________________________________________________ 

           __________215_____________________________________ 
 1mbt    : PQQVFNAVCHMRTTKLPDPKVNGNAGSFFKNPVVSAETAKALLSQFPTAP 
         :                                                    
 1uxy    : PQQVFNAVCHMRTTKLPDPKVNGNAGAFFKNPVVSAETAKALLSQFPTAP 
           __________215_____________________________________ 

           _____________________276____283___________________ 
 1mbt    : NYPQADGSVKLAAGWLIDQCQLKGMQIGGAAVHRQQALVLINEDNAKSED 
         :                                                    
 1uxy    : NYPQADGSVKLAAGWLIDQCQLKGMQIGGAAVHRQQALVLINEDNAKSED 
           _____________________276____283___________________ 

           ___________________324_______334________           
 1mbt    : VVQLAHHVRQKVGEKFNVWLEPEVRFIGASGEVSAVETIS           
         :                                                    
 1uxy    : VVQLAHHVRQKVGEKFNVWLEPEVRFIGASGEVSAVETIS           
           ___________________324_______334________           

Details

  Property   Value
 Conformer 1 1mbt( )
 Conformer 2 1uxy( )
 Radius gyration for conformer 1 20.45 A
 Radius gyration for conformer 2 20.34 A
 EC Number 1.1.1.158  
Click here to see the DynDom results or the famliy
 Trigger ligands EPU402
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact Yes
 Spanning ligands Yes
 Residues in enzyme contacting ligands ALA124  ALA229  ALA264  ALA289  ARG159  ARG214  ASN233  ASP270  GLN288  GLU325  GLY228  GLY266  LEU218  LEU290  LYS217  LYS232  LYS275  PHE231  PRO252  TRP267  TYR125  TYR158  TYR190  TYR254 
 Residues in extended bending regions contacting ligands ALA289  ARG214  GLN288  GLU325  LEU218  LYS217  LYS275 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands ALA289  ARG214  GLN288  GLU325 
  Residues in extended bending regions with an H-bond between its main chain and ligands ALA289 
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT