ASPARTATE AMINOTRANSFERASE
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           _________________________________39_______________ 
 1ix8(A) : MFENITAAPADPILGLADLFRADERPGKINLGIGFYKDETGKTPVLTSVK 
         :                                                    
 1toi(A) : MFENITAAPADPILGLADLFRADERPGKINLGIGLYYDETGKIPVLTSVK 
           _________________________________39_______________ 

           __________________________________________________ 
 1ix8(A) : KAEQYLLENETTKNYLGIDGIPEFGRCTQELLFGKGSALINDKRARTAQT 
         :                                                    
 1toi(A) : KAEQYLLENETTKLYLGIDGIPEFGRCTQELLFGKGSALINDKRARTAQT 
           __________________________________________________ 

           __________________________________________________ 
 1ix8(A) : PGGTGALRVAADFLAKNTSVKRVWVSNPSWPNHKSVFNSAGLEVREYAYY 
         :                                                    
 1toi(A) : PGGSGALRVAADFLAKNTSVKRVWVSNPSWPNHKSVFNSAGLEVREYAYY 
           __________________________________________________ 

           __________________________________________________ 
 1ix8(A) : DAENHTLDFDALINSLNEAQAGDVVLFHGCCHAPTGIDPTLEQWQTLAQL 
         :                                                    
 1toi(A) : DAENHTLDFDALINSLNEAQAGDVVLFHGCCHNPTGIDPTLEQWQTLAQL 
           __________________________________________________ 

           __________________________________________________ 
 1ix8(A) : SVEKGWLPLFDFAYQGFARGLEEDAEGLRAFAAMHKELIVASSYSKNFGL 
         :                                                    
 1toi(A) : SVEKGWLPLFDFAYQGFARGLEEDAEGLRAFAAMHKELIVASSYS-nFGL 
           __________________________________________________ 

           __________________________________________________ 
 1ix8(A) : YNERVGACTLVAADSETVDRAFSQMKAAIRANYSNPPAHGASVVATILSN 
         :                                                    
 1toi(A) : YNERVGACTLVAADSETVDRAFSQMKAAIRDNYSSPPAHGASVVATILSN 
           __________________________________________________ 

           _____________328_____________________352__________ 
 1ix8(A) : DALRAIWEQELTDMRQRIQRMRQLFVNTLQEKGANRDFSFIIKQNGMFSF 
         :                                                    
 1toi(A) : DALRAIWEQELTDMRQRIQRMRQLFVNTLQEKGANRDFSFIIKQNGMFSF 
           _____________328_____________________352__________ 

           ______________________________________________     
 1ix8(A) : SGLTKEQVLRLREEFGVYAVASGRVNVAGMTPDNMAPLCEAIVAVL     
         :                                                    
 1toi(A) : SGLTKEQVLRLREEFGVYAVASGRVNVAGMTPDNMAPLCEAIVAVL     
           ______________________________________________     

Details

  Property   Value
 Conformer 1 1ix8(A)
 Conformer 2 1toi(A)
 Radius gyration for conformer 1 21.75 A
 Radius gyration for conformer 2 21.33 A
 EC Number 2.6.1.1  
Click here to see the DynDom results or the famliy
 Trigger ligands PLP413
 Trigger ligands in which conformation Conformation  1
 Conformaton with trigger ligands is compact No
 Spanning ligands No
 Residues in enzyme contacting ligands ALA224  ARG266  ASP222  GLY107  GLY108  HIS189  LYS258  SER255  SER257  THR109  TRP140  TYR225 
 Residues in extended bending regions contacting ligands Null
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT