CARBON MONOXIDE DEHYDROGENASE ALPHA SUBUNIT
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1oao(D) : TDFDKIFEGAIPEGKEPVALFREVYHGAITATSYAEILLNQAIRTYGPDH 
         :                                                    
 1mjg(N) : TDFDKIFEGAIPEGKEPVALFREVYHGAITATSYAEILLNQAIRTYGPDH 
           __________________________________________________ 

           __________________________________________________ 
 1oao(D) : PVGYPDTAYYLPVIRCFSGEEVKKLGDLPPILNRKRAQVSPVLNFENARL 
         :                                                    
 1mjg(N) : PVGYPDTAYYLPVIRCFSGEEVKKLGDLPPILNRKRAQVSPVLNFENARL 
           __________________________________________________ 

           __________________________________________________ 
 1oao(D) : AGEATWYAAEIIEALRYLKYKPDEPLLPPPWTGFIGDPVVRRFGIKMVDW 
         :                                                    
 1mjg(N) : AGEATWYAAEIIEALRYLKYKPDEPLLPPPWTGFIGDPVVRRFGIKMVDW 
           __________________________________________________ 

           __________________________________________________ 
 1oao(D) : TIPGEAIILGRAKDSKALAKIVKELMGMGFMLFICDEAVEQLLEENVKLG 
         :                                                    
 1mjg(N) : TIPGEAIILGRAKDSKALAKIVKELMGMGFMLFICDEAVEQLLEENVKLG 
           __________________________________________________ 

           __________________________________________________ 
 1oao(D) : IDYIAYPLGNFTQIVHAANYALRAGMMFGGVTPGAREEQRDYQRRRIRAF 
         :                                                    
 1mjg(N) : IDYIAYPLGNFTQIVHAANYALRAGMMFGGVTPGAREEQRDYQRRRIRAF 
           __________________________________________________ 

           __________________________________________________ 
 1oao(D) : VLYLGEHDMVKTAAAFGAIFTGFPVITDQPLPEDKQIPDWFFSVEDYDKI 
         :                                                    
 1mjg(N) : VLYLGEHDMVKTAAAFGAIFTGFPVITDQPLPEDKQIPDWFFSVEDYDKI 
           __________________________________________________ 

           _______311________________________________________ 
 1oao(D) : VQIAMETRGIKLTKIKLDLPINFGPAFEGESIRKGDMYVEMGGNRTPAFE 
         :                                                    
 1mjg(N) : VQIAMETRGIKLTKIKLDLPINFGPAFEGESIRKGDMYVEMGGNRTPAFE 
           _______311________________________________________ 

           __________________________________________________ 
 1oao(D) : LVRTVSESEITDGKIEVIGPDIDQIPEGSKLPLGILVDIYGRKMQADFEG 
         :                                                    
 1mjg(N) : LVRTVSESEITDGKIEVIGPDIDQIPEGSKLPLGILVDIYGRKMQADFEG 
           __________________________________________________ 

           __________________________________________________ 
 1oao(D) : VLERRIHDFINYGEGLWHTGQRNINWLRVSKDAVAKGFRFKNYGEILVAK 
         :                                                    
 1mjg(N) : VLERRIHDFINYGEGLWHTGQRNINWLRVSKDAVAKGFRFKNYGEILVAK 
           __________________________________________________ 

           __________________________________________________ 
 1oao(D) : MKEEFPAIVDRVQVTIFTDEAKVKEYMEVAREKYKERDDRMRGLTDETVD 
         :                                                    
 1mjg(N) : MKEEFPAIVDRVQVTIFTDEAKVKEYMEVAREKYKERDDRMRGLTDETVD 
           __________________________________________________ 

           __________________________________________________ 
 1oao(D) : TFYSCVLCQSFAPNHVCIVTPERVGLCGAVSWLDAKASYEINHAGPNQPI 
         :                                                    
 1mjg(N) : TFYSCVLCQSFAPNHVCIVTPERVGLCGAVSWLDAKASYEINHAGPNQPI 
           __________________________________________________ 

           __________________________________________________ 
 1oao(D) : PKEGEIDPIKGIWKSVNDYLYTASNRNLEQVCLYTLMENPMTSCGCFEAI 
         :                                                    
 1mjg(N) : PKEGEIDPIKGIWKSVNDYLYTASNRNLEQVCLYTLMENPMTSCGCFEAI 
           __________________________________________________ 

           __________________________________________________ 
 1oao(D) : MAILPECNGIMITTRDHAGMTPSGMTFSTLAGMIGGGTQTPGFMGIGRTY 
         :                                                    
 1mjg(N) : MAILPECNGIMITTRDHAGMTPSGMTFSTLAGMIGGGTQTPGFMGIGRTY 
           __________________________________________________ 

           __________________________________________________ 
 1oao(D) : IVSKKFISADGGIARIVWMPKSLKDFLHDEFVRRSVEEGLGEDFIDKIAD 
         :                                                    
 1mjg(N) : IVSKKFISADGGIARIVWMPKSLKDFLHDEFVRSSVEEGLGEDFIDKIAD 
           __________________________________________________ 

           ____________________________                       
 1oao(D) : ETIGTTVDEILPYLEEKGHPALTMDPIM                       
         :                                                    
 1mjg(N) : ETIGTTVDEILPYLEEKGHPALTMDPIM                       
           ____________________________                       

Details

  Property   Value
 Conformer 1 1oao(D)
 Conformer 2 1mjg(N)
 Radius gyration for conformer 1 28.59 A
 Radius gyration for conformer 2 27.25 A
 EC Number 1.2.99.2  
Click here to see the DynDom results or the famliy
 Trigger ligands ACT950
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact Yes
 Spanning ligands Yes
 Residues in enzyme contacting ligands CYS509  CYS595  CYS597  GLY145  ILE146  PHE229  VAL149 
 Residues in extended bending regions contacting ligands Null
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT