PROTEIN (CATALASE HPII)
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1ggk(C) : DSLAPEDGSHRPAAEPTPPGAQPTAPGSLKAPDTRNEKLNSLEDVRKGSE 
         :                                                    
 1gg9(A) : DSLAPEDGSHRPAAEPTPPGAQPTAPGSLKAPDTRNEKLNSLEDVRKGSE 
           __________________________________________________ 

           __________________________________________________ 
 1ggk(C) : NYALTTNQGVRIADDQNSLRAGSRGPTLLEDFILREKITHFDHERIPERI 
         :                                                    
 1gg9(A) : NYALTTNQGVRIADDQNSLRAGSRGPTLLEDFILREKITHFDHERIPERI 
           __________________________________________________ 

           __________________________________________________ 
 1ggk(C) : VHARGSAAHGYFQPYKSLSDITKADFLSDPNKITPVFVRFSTVQGGAGSA 
         :                                                    
 1gg9(A) : VNARGSAAHGYFQPYKSLSDITKADFLSDPNKITPVFVRFSTVQGGAGSA 
           __________________________________________________ 

           __________________________________________________ 
 1ggk(C) : DTVRDIRGFATKFYTEEGIFDLVGHNTPIFFIQDAHKFPDFVHAVKPEPH 
         :                                                    
 1gg9(A) : DTVRDIRGFATKFYTEEGIFDLVGNNTPIFFIQDAHKFPDFVHAVKPEPH 
           __________________________________________________ 

           __________________________________________________ 
 1ggk(C) : WAIPQGQSAHDTFWDYVSLQPETLHNVMWAMSDRGIPRSYRTMEGFGIHT 
         :                                                    
 1gg9(A) : WAIPQGQSAHDTFWDYVSLQPETLHNVMWAMSDRGIPRSYRTMEGFGIHT 
           __________________________________________________ 

           __________________________________________________ 
 1ggk(C) : FRLINAEGKATFVRFHWKPLAGKASLVWDEAQKLTGRDPDFHRRELWEAI 
         :                                                    
 1gg9(A) : FRLINAEGKATFVRFHWKPLAGKASLVWDEAQKLTGRDPDFHRRELWEAI 
           __________________________________________________ 

           __________________________________________________ 
 1ggk(C) : EAGDFPEYELGFQLIPEEDEFKFDFDLLDPTKLIPEELVPVQRVGKMVLN 
         :                                                    
 1gg9(A) : EAGDFPEYELGFQLIPEEDEFKFDFDLLDPTKLIPEELVPVQRVGKMVLN 
           __________________________________________________ 

           __________________________________________________ 
 1ggk(C) : RNPDNFFAENEQAAFHPGHIVPGLDFTNDPLLQGRLFSYTDTQISRLGGP 
         :                                                    
 1gg9(A) : RNPDNFFAENEQAAFHPGHIVPGLDFTNDPLLQGRLFSYTDTQISRLGGP 
           __________________________________________________ 

           __________________________________________________ 
 1ggk(C) : NFHEIPINRPTCPYHNFQRDGMHRMGIDTNPANYEPNSINDNWPRETPPG 
         :                                                    
 1gg9(A) : NFHEIPINRPTCPYHNFQRDGMHRMGIDTNPANYEPNSINDNWPRETPPG 
           __________________________________________________ 

           __________________________________________________ 
 1ggk(C) : PKRGGFESYQERVEGNKVRERSPSFGEYYSHPRLFWLSQTPFEQRHIVDG 
         :                                                    
 1gg9(A) : PKRGGFESYQERVEGNKVRERSPSFGEYYSHPRLFWLSQTPFEQRHIVDG 
           __________________________________________________ 

           __________________________________________________ 
 1ggk(C) : FSFELSKVVRPYIRERVVDQLAHIDLTLAQAVAKNLGIELTDDQLNITPP 
         :                                                    
 1gg9(A) : FSFELSKVVRPYIRERVVDQLAHIDLTLAQAVAKNLGIELTDDQLNITPP 
           __________________________________________________ 

           __________________________________________________ 
 1ggk(C) : PDVNGLKKDPSLSLYAIPDGDVKGRVVAILLNDEVRSADLLAILKALKAK 
         :                                                    
 1gg9(A) : PDVNGLKKDPSLSLYAIPDGDVKGRVVAILLNDEVRSADLLAILKALKAK 
           __________________________________________________ 

           ____633_____________________657___________________ 
 1ggk(C) : GVHAKLLYSRMGEVTADDGTVLPIAATFAGAPSLTVDAVIVPCGNIADIA 
         :                                                    
 1gg9(A) : GVHAKLLYSRMGEVTADDGTVLPIAATFAGAPSLTVDAVIVPCGNIADIA 
           ____633_____________________657___________________ 

           __________________________________________________ 
 1ggk(C) : DNGDANYYLMEAYKHLKPIALAGDARKFKATIKIADQGEEGIVEADSADG 
         :                                                    
 1gg9(A) : DNGDANYYLMEAYKHLKPIALAGDARKFKATIKIADQGEEGIVEADSADG 
           __________________________________________________ 

           ___________________________                        
 1ggk(C) : SFMDELLTLMAAHRVWSRIPKIDKIPA                        
         :                                                    
 1gg9(A) : SFMDELLTLMAAHRVWSRIPKIDKIPA                        
           ___________________________                        

Details

  Property   Value
 Conformer 1 1ggk(C)
 Conformer 2 1gg9(A)
 Radius gyration for conformer 1 28.62 A
 Radius gyration for conformer 2 28.11 A
 EC Number 1.11.1.6  
Click here to see the DynDom results or the famliy
 Trigger ligands HEM760
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact Yes
 Spanning ligands No
 Residues in enzyme contacting ligands ASP118 
 Residues in extended bending regions contacting ligands Null
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT