delta1-piperideine-2-carboxylate reductase
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 2cwf(A) : ***TQTVSYPQLIDLLRRIFVVHGTSPEVADVLAENCASAQRDGSHSHGI 
         :                                                    
 1wtj(B) : DQPTQTVSYPQLIDLLRRIFVVHGTSPEVADVLAENCASAQRDGSHSHGI 
           __________________________________________________ 

           __________________________________________________ 
 2cwf(A) : FRIPGYLSSLASGWVDGKAVPVVEDVGAAFVRVDACNGFAQPALAAARSL 
         :                                                    
 1wtj(B) : FRIPGYLSSLASGWVDGKAVPVVEDVGAAFVRVDACNGFAQPALAAARSL 
           __________________________________________________ 

           __________________________________________________ 
 2cwf(A) : LIDKARSAGVAILAIRGSHHFAALWPDVEPFAEQGLVALSMVNSMTCVVP 
         :                                                    
 1wtj(B) : LIDKARSAGVAILAIRGSHHFAALWPDVEPFAEQGLVALSMVNSMTCVVP 
           __________________________________________________ 

           ______________________________189_________________ 
 2cwf(A) : HGARQPLFGTNPIAFGAPRAGGEPIVFDLATSAIAHGDVQIAAREGRLLP 
         :                                                    
 1wtj(B) : HGARQPLFGTNPIAFGAPRAGGEPIVFDLATSAIAHGDVQIAAREGRLLP 
           ______________________________189_________________ 

           ____________________229___________________________ 
 2cwf(A) : AGMGVDRDGLPTQEPRAILDGGALLPFGGHKGSALSMMVELLAAGLTGGN 
         :                                                    
 1wtj(B) : AGMGVDRDGLPTQEPRAILDGGALLPFGGHKGSALSMMVELLAAGLTGGN 
           ____________________229___________________________ 

           __________________________________________________ 
 2cwf(A) : FSFEFDWSKHPGAQTPWTGQLLIVIDPDKGAGQHFAQRSEELVRQLHGVG 
         :                                                    
 1wtj(B) : FSFEFDWSKHPGAQTPWTGQLLIVIDPDKGAGQHFAQRSEELVRQLHGVG 
           __________________________________________________ 

           _____________________________________              
 2cwf(A) : QERLPGDRRYLERARSMAHGIVIAQADLERLQELA**              
         :                                                    
 1wtj(B) : QERLPGDRRYLERARSMAHGIVIAQADLERLQELAGH              
           _____________________________________              

Details

  Property   Value
 Conformer 1 2cwf(A)
 Conformer 2 1wtj(B)
 Radius gyration for conformer 1 19.92 A
 Radius gyration for conformer 2 19.72 A
 EC Number 1.1.1.154  
Click here to see the DynDom results or the famliy
 Trigger ligands NDP2510
 Trigger ligands in which conformation Conformation  1
 Conformaton with trigger ligands is compact No
 Spanning ligands Yes
 Residues in enzyme contacting ligands ALA128  ALA129  ALA186  ALA191  ARG309  ARG314  ARG315  ASP184  ASP313  GLY312  HIS126  HIS54  LEU130  LEU185  PHE183  PRO168  PRO311  SER150  THR166  VAL182 
 Residues in extended bending regions contacting ligands ALA186  ALA191 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands ALA186 
  Residues in extended bending regions with an H-bond between its main chain and ligands ALA186 
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT