FUMARYLACETOACETATE HYDROLASE
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 2hzy(B) : GSMSFIPVAEDSDFPIQNLPYGVFSTQSNPKPRIGVAIGDQILDLSVIKH 
         :                                                    
 1hyo(B) : GSMSFIPVAEDSDFPIQNLPYGVFSTQSNPKPRIGVAIGDQILDLSVIKH 
           __________________________________________________ 

           __________________________________________________ 
 2hzy(B) : LFTGPALSKHQHVFDETTLNNFMGLGQAAWKEARASLQNLLSASQARLRD 
         :                                                    
 1hyo(B) : LFTGPALSKHQHVFDETTLNNFMGLGQAAWKEARASLQNLLSASQARLRD 
           __________________________________________________ 

           __________________________127_____________________ 
 2hzy(B) : DKELRQRAFTSQASATMHLPATIGDYTDFYSSRQHATNVGIMFRGKENAL 
         :                                                    
 1hyo(B) : DKELRQRAFTSQASATMHLPATIGDYTDFYSSRQHATNVGIMFRGKENAL 
           __________________________627_____________________ 

           __________________________________________________ 
 2hzy(B) : LPNWLHLPVGYHGRASSIVVSGTPIRRPMGQMRPDNSKPPVYGACRLLDM 
         :                                                    
 1hyo(B) : LPNWLHLPVGYHGRASSIVVSGTPIRRPMGQMRPDNSKPPVYGACRLLDM 
           __________________________________________________ 

           __________________________________________________ 
 2hzy(B) : ELEMAFFVGPGNRFGEPIPISKAHEHIFGMVLMNDWSARDIQQWEYVPLG 
         :                                                    
 1hyo(B) : ELEMAFFVGPGNRFGEPIPISKAHEHIFGMVLMNDWSARDIQQWEYVPLG 
           __________________________________________________ 

           __________________________________________________ 
 2hzy(B) : PFLGKSFGTTISPWVVPMDALMPFVVPNPKQDPKPLPYLCHSQPYTFDIN 
         :                                                    
 1hyo(B) : PFLGKSFGTTISPWVVPMDALMPFVVPNPKQDPKPLPYLCHSQPYTFDIN 
           __________________________________________________ 

           ________________________________________________34 
 2hzy(B) : LSVSLKGEGMSQAATICRSNFKHMYWTMLQQLTHHSVNGCNLRPGDLLAS 
         :                                                    
 1hyo(B) : LSVSLKGEGMSQAATICRSNFKHMYWTMLQQLTHHSVNGCNLRPGDLLAS 
           ________________________________________________84 

           9_____________________373_________________________ 
 2hzy(B) : GTISGSDPESFGSMLELSWKGTKAIDVGQGQTRTFLLDGDEVIITGHCQG 
         :                                                    
 1hyo(B) : GTISGSDPESFGSMLELSWKGTKAIDVGQGQTRTFLLDGDEVIITGHCQG 
           9_____________________873_________________________ 

           ___________________                                
 2hzy(B) : DGYRVGFGQCAGKVLPAL*                                
         :                                                    
 1hyo(B) : DGYRVGFGQCAGKVLPALS                                
           ___________________                                

Details

  Property   Value
 Conformer 1 2hzy(B)
 Conformer 2 1hyo(B)
 Radius gyration for conformer 1 21.88 A
 Radius gyration for conformer 2 21.91 A
 EC Number 3.7.1.2  
Click here to see the DynDom results or the famliy
 Trigger ligands ACT1010
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact No
 Spanning ligands Yes
 Residues in enzyme contacting ligands ARG642  LEU649  TYR628  VAL637 
 Residues in extended bending regions contacting ligands ARG642  LEU649  TYR628  VAL637 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT