PHOSPHOSERINE PHOSPHATASE (PSP)
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           _________________________529____________________55 
 1l7o(B) : **KKKLILFNFDSTLVNNETIDEIAREAGVEEEVKKITKEAeGKLNFEQS 
         :                                                    
 1l7p(B) : EKKKKLILFNFDSTLVNNETIDEIAREAGVEEEVKKITKEAeGKLNFEQS 
           _________________________529____________________55 

           3_________________________________________________ 
 1l7o(B) : LRKRVSLLKDLPIEKVEKAIKRITPTEGAEETIKELKNRGYVVAVVSGGF 
         :                                                    
 1l7p(B) : LRKRVSLLKDLPIEKVEKAIKRITPTEGAEETIKELKNRGYVVAVVSGGF 
           3_________________________________________________ 

           __________________________________________________ 
 1l7o(B) : DIAVNKIKEKLGLDYAFANRLIVKDGKLTGDVEGEVLKENAKGEILEKIA 
         :                                                    
 1l7p(B) : DIAVNKIKEKLGLDYAFANRLIVKDGKLTGDVEGEVLKENAKGEILEKIA 
           __________________________________________________ 

           __________________________________________________ 
 1l7o(B) : KIEGINLEDTVAVGDGANDISfKKAGLKIAFCAKPILKEKADICIEKRDL 
         :                                                    
 1l7p(B) : KIEGINLEDTVAVGDGANDISfKKAGLKIAFCAKPILKEKADICIEKRDL 
           __________________________________________________ 

           ________                                           
 1l7o(B) : REILKYIK                                           
         :                                                    
 1l7p(B) : REILKYIK                                           
           ________                                           

Details

  Property   Value
 Conformer 1 1l7o(B)
 Conformer 2 1l7p(B)
 Radius gyration for conformer 1 16.99 A
 Radius gyration for conformer 2 16.69 A
 EC Number 3.1.3.3  
Click here to see the DynDom results or the famliy
 Trigger ligands SEP270
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact Yes
 Spanning ligands Yes
 Residues in enzyme contacting ligands ARG556  ASN511  ASN670  ASP513  GLU520  GLY600  GLY601  LEU553  LYS644  PHE512  PHE549  SER599 
 Residues in extended bending regions contacting ligands ARG556  LEU553 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT