Serine acetyltransferase
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1sst(C) : MTLDVWQHIRQEAKELAENEPMLASFFHSTILKHQNLGGALSYLLANKLA 
         :                                                    
 1ssq(D) : MNLDVWQHIRQEAKELAENEPMLASFFHSTILKHQNLGGALSYLLANKLA 
           __________________________________________________ 

           ______________________________82________________10 
 1sst(C) : NPIMPAISLREIIEEAYQSNPSIIDCAACDIQAVRHRDPAVELWSTPLLY 
         :                                                    
 1ssq(D) : NPIMPAISLREIIEEAYQSNPSIIDCAACDIQAVRHRDPAVELWSTPLLY 
           ______________________________82________________10 

           1_________________________________________________ 
 1sst(C) : LKGFHAIQSYRITHYLWNQNRKSLALYLQNQISVAFDVDIHPAAKIGHGI 
         :                                                    
 1ssq(D) : LKGFHAIQSYRITHYLWNQNRKSLALYLQNQISVAFDVDIHPAAKIGHGI 
           1_________________________________________________ 

           __________________________________________________ 
 1sst(C) : MFDHATGIVVGETSVIENDVSILQGVTLGGTg----DRHPKVREGVMIGA 
         :                                                    
 1ssq(D) : MFDHATGIVVGETSVIENDVSILQGVTLGGTGKESGDRHPKVREGVMIGA 
           __________________________________________________ 

           __________________________________________________ 
 1sst(C) : GAKILGNIEVGKYAKIGANSVVLNPVPEYATAAGVPARIV********** 
         :                                                    
 1ssq(D) : GAKILGNIEVGKYAKIGANSVVLNPVPEYATAAGVPARIVSQDKAAKPAF 
           __________________________________________________ 

           _______                                            
 1sst(C) : *******                                            
         :                                                    
 1ssq(D) : DMNQYFI                                            
           _______                                            

Details

  Property   Value
 Conformer 1 1sst(C)
 Conformer 2 1ssq(D)
 Radius gyration for conformer 1 18.01 A
 Radius gyration for conformer 2 18 A
 EC Number 2.3.1.30  
Click here to see the DynDom results or the famliy
 Trigger ligands COA400
COA500
 Trigger ligands in which conformation Conformation  1
 Conformaton with trigger ligands is compact No
 Spanning ligands No
 Residues in enzyme contacting ligands ALA200  ALA218  ALA233  GLN174  GLY180  GLY199  GLY217  GLY234  HIS154  LEU173  LEU205  LEU223  PRO236  THR177  THR181  THR231  VAL221  VAL235  VAL240 
 Residues in extended bending regions contacting ligands Null
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT