UDP-N-ACETYLGLUCOSAMINE PYROPHOSPHORYLASE
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           ___________15_________________34__________________ 
 1fwy(B) : NNAMSVVILAAGKGTRMYSDLPKVLHTLAGKAMVQHVIDAANELGAAHVH 
         :                                                    
 1fxj(A) : NNAMSVVILAAGKGTRMYSDLPKVLHTLAGKAMVQHVIDAANELGAAHVH 
           ___________15_________________34__________________ 

           ___________65_________________________________101_ 
 1fwy(B) : LVYGHGGDLLKQALKDDNLNWVLQAEQLGTGHAMQQAAPFFADDEDILML 
         :                                                    
 1fxj(A) : LVYGHGGDLLKQALKDDNLNWVLQAEQLGTGHAMQQAAPFFADDEDILML 
           ___________65_________________________________101_ 

           105_______________________________________________ 
 1fwy(B) : YGDVPLISVETLQRLRDAKPQGGIGLLTVKLDDPTGYGRITRENGKVTGI 
         :                                                    
 1fxj(A) : YGDVPLISVETLQRLRDAKPQGGIGLLTVKLDDPTGYGRITRENGKVTGI 
           105_______________________________________________ 

           __________________________________________________ 
 1fwy(B) : VEHKDATDEQRQIQEINTGILIANGADMKRWLAKLTNNNAQGEYYITDII 
         :                                                    
 1fxj(A) : VEHKDATDEQRQIQEINTGILIANGADMKRWLAKLTNNNAQGEYYITDII 
           __________________________________________________ 

           ______________________227_________________________ 
 1fwy(B) : ALAYQEGREIVAVHPQRLSEVEGVNNRLQLSRLERVYQSEQAEKLLLAGV 
         :                                                    
 1fxj(A) : ALAYQEGREIVAVHPQRLSEVEGVNNRLQLSRLERVYQSEQAEKLLLAGV 
           ______________________227_________________________ 

           __________________________________________________ 
 1fwy(B) : MLRDPARFDLRGTLTHGRDVEIDTNVIIEGNVTLGHRVKIGTGCVIKNSV 
         :                                                    
 1fxj(A) : MLRDPARFDLRGTLTHGRDVEIDTNVIIEGNVTLGHRVKIGTGCVIKNSV 
           __________________________________________________ 

           ___________________________                        
 1fwy(B) : IGDDCEISPYTVVEDANLAAACTI***                        
         :                                                    
 1fxj(A) : IGDDCEISPYTVVEDANLAAACTIGPF                        
           ___________________________                        

Details

  Property   Value
 Conformer 1 1fwy(B)
 Conformer 2 1fxj(A)
 Radius gyration for conformer 1 22.21 A
 Radius gyration for conformer 2 22.33 A
 EC Number 2.7.7.23  
Click here to see the DynDom results or the famliy
 Trigger ligands UD1502
 Trigger ligands in which conformation Conformation  1
 Conformaton with trigger ligands is compact Yes
 Spanning ligands Yes
 Residues in enzyme contacting ligands ALA12  ALA13  ALA85  ASN169  ASP105  GLN76  GLN79  GLU154  GLY104  GLY14  GLY140  GLY81  ILE198  LEU11  LEU80  THR199  THR82  TYR103  TYR139  TYR197 
 Residues in extended bending regions contacting ligands ALA12  ALA13  ASP105  GLY104  GLY14  TYR103 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands ALA13  ASP105  GLY14  TYR103 
  Residues in extended bending regions with an H-bond between its main chain and ligands ALA13  GLY14 
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT