GLUCOSE 6-PHOSPHATE DEHYDROGENASE
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1dpg(B) : VSEIKTLVTFFGGTGDLAKRKLYPSVFNLYKKGYLQKHFAIVGTARQALN 
         :                                                    
 2dpg    : VSEIKTLVTFFGGTGDLAKRKLYPSVFNLYKKGYLQKHFAIVGTARQALN 
           __________________________________________________ 

           __________________________________________________ 
 1dpg(B) : DDEFKQLVRDCIKDFTDDQAQAEAFIEHFSYRAHDVTDAASYAVLKEAIE 
         :                                                    
 2dpg    : DDEFKQLVRDSIKDFTDDQAQAEAFIEHFSYRAHDVTDAASYAVLKEAIE 
           __________________________________________________ 

           ___________________________________________146____ 
 1dpg(B) : EAADKFDIDGNRIFYMSVAPRFFGTIAKYLKSEGLLADTGYNRLMIEKPF 
         :                                                    
 2dpg    : EAADKFDIDGNRIFYMSVAPRFFGTIAKYLKSEGLLADTGYNRLMIEKPF 
           ___________________________________________146____ 

           ___________164________175_________________________ 
 1dpg(B) : GTSYDTAAELQNDLENAFDDNQLFRIDHYLGKEMVQNIAALRFGNPIFDA 
         :                                                    
 2dpg    : GTSYDTAAELQNDLENAFDDNQLFRIDHYLGKEMVQNIAALRFGNPIFDA 
           ___________164________175_________________________ 

           __________________________________________________ 
 1dpg(B) : AWNKDYIKNVQVTLSEVLGVEERAGYYDTAGALLDMIQNHTMQIVGWLAM 
         :                                                    
 2dpg    : AWNKDYIKNVQVTLSEVLGVEERAGYYDTAGALLDMIQNNTMQIVGWLAM 
           __________________________________________________ 

           __________________________________________________ 
 1dpg(B) : EKPESFTDKDIRAAKNAAFNALKIYDEAEVNKYFVRAQYGAGDSADFKPY 
         :                                                    
 2dpg    : EKPESFTDKDIRAAKNAAFNALKIYDEAEVNKYFVRAQYGAGDSADFKPY 
           __________________________________________________ 

           __________________________________________________ 
 1dpg(B) : LEELDVPADSKNNTFIAGELQFDLPRWEGVPFYVRSGKRLAAKQTRVDIV 
         :                                                    
 2dpg    : LEELDVPADSKNNTFIAGELQFDLPRWEGVPFYVRSGKRLAAKQTRVDIV 
           __________________________________________________ 

           __________________________________________________ 
 1dpg(B) : FKAGTFNFGSEQEAQEAVLSIIIDPKGAIELKLNAKSVEDAFNTRTIDLG 
         :                                                    
 2dpg    : FKAGTFNFGSEQEAQEAVLSIIIDPKGAIELKLNAKSVEDAFNTRTIDLG 
           __________________________________________________ 

           ____407_______________425_________________________ 
 1dpg(B) : WTVSDEDKKNTPEPYERMIHDTMNGDGSNFADWNGVSIAWKFVDAISAVY 
         :                                                    
 2dpg    : WTVSDEDKKNTPEPYERMIHDTMNGDGSNFADWNGVSIAWKFVDAISAVY 
           ____407_______________425_________________________ 

           ___________________________________                
 1dpg(B) : TADKAPLETYKSGSMGPEASDKLLAANGDAWVFKG                
         :                                                    
 2dpg    : TADKAPLETYKSGSMGPEASDKLLAANGDAWVFKG                
           ___________________________________                

Details

  Property   Value
 Conformer 1 1dpg(B)
 Conformer 2 2dpg( )
 Radius gyration for conformer 1 24.41 A
 Radius gyration for conformer 2 24.61 A
 EC Number 1.1.1.49  
Click here to see the DynDom results or the famliy
 Trigger ligands NAP799
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact No
 Spanning ligands No
 Residues in enzyme contacting ligands ALA45  ARG46  ASP16  ASP85  GLN47  GLY12  GLY15  HIS84  LEU17  PHE122  SER117  THR14  VAL118  VAL86 
 Residues in extended bending regions contacting ligands Null
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT