L-3-HYDROXYACYL-COA DEHYDROGENASE
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1f0y(A) : KIIVKHVTVIGGGLMGAGIAQVAAATGHTVVLVDQTEDILAKSKKGIEES 
         :                                                    
 1f17(B) : KIIVKHVTVIGGGLMGAGIAQVAAATGHTVVLVDQTEDILAKSKKGIEES 
           __________________________________________________ 

           __________________________________________________ 
 1f0y(A) : LRKVAKKKFAENPKAGDEFVEKTLSTIATSTDAASVVHSTDLVVEAIVEN 
         :                                                    
 1f17(B) : LRKVAKKKFAENPKAGDECVEKTLSTIATSTDAASVVHSTDLVVEAIVEN 
           __________________________________________________ 

           __________________________________________________ 
 1f0y(A) : LKVKNELFKRLDKFAAEHTIFASNTSSLQITSIANATTRQDRFAGLHFFN 
         :                                                    
 1f17(B) : LKVKNELFKRLDKFAAEHTIFASNTSSLQITSIANATTRQDRFAGLHFFN 
           __________________________________________________ 

           ___________________________________199____________ 
 1f0y(A) : PVPVMKLVEVIKTPMTSQKTFESLVDFSKALGKHPVSCKDTPGFIVNRLL 
         :                                                    
 1f17(B) : PVPVMKLVEVIKTPMTSQKTFESLVDFSKALGKHPVSCKDTPGFIVNRLL 
           ___________________________________199____________ 

           __________________________________________________ 
 1f0y(A) : VPYLMEAIRLYERGDASKEDIDTAMKLGAGYPMGPFELLDYVGLDTTKFI 
         :                                                    
 1f17(B) : VPYLMEAIRLYERGDASKEDIDTAMKLGAGYPMGPFELLDYVGLDTTKFI 
           __________________________________________________ 

           _________________________________________          
 1f0y(A) : VDGWHEMDAENPLHQPSPSLNKLVAENKFGKKTGEGFYKYK          
         :                                                    
 1f17(B) : VDGWHEMDAENPLHQPSPSLNKLVAENKFGKKTGEGFYKYK          
           _________________________________________          

Details

  Property   Value
 Conformer 1 1f0y(A)
 Conformer 2 1f17(B)
 Radius gyration for conformer 1 19.54 A
 Radius gyration for conformer 2 20.36 A
 EC Number 1.1.1.35  
Click here to see the DynDom results or the famliy
 Trigger ligands NAD350
 Trigger ligands in which conformation Conformation  1
 Conformaton with trigger ligands is compact Yes
 Spanning ligands Yes
 Residues in enzyme contacting ligands ALA107  ASN135  ASN161  ASP45  GLN46  GLU110  GLY22  GLY23  GLY24  HIS158  ILE108  ILE21  ILE50  LEU25  LYS115  LYS293  MET26  PHE159  SER137  THR257  VAL253 
 Residues in extended bending regions contacting ligands Null
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT