Methylene Tetrahydromethanopterin Dehydrogena
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1lu9(A) : SKKLLFQFDTDATPSVFDVVVGYDGGADHITGYGNVTPDNVGAYVDGTIY 
         :                                                    
 1lua(C) : SKKLLFQFDTDATPSVFDVVVGYDGGADHITGYGNVTPDNVGAYVDGTIY 
           __________________________________________________ 

           __________________________________________95______ 
 1lu9(A) : TRGGKEKQSTAIFVGGGDMAAGERVFEAVKKRFFGPFRVSCMLDSNGSNT 
         :                                                    
 1lua(C) : TRGGKEKQSTAIFVGGGDMAAGERVFEAVKKRFFGPFRVSCMLDSNGSNT 
           __________________________________________95______ 

           __________________________________________________ 
 1lu9(A) : TAAAGVALVVKAAGGSVKGKKAVVLAGTGPVGMRSAALLAGEGAEVVLCG 
         :                                                    
 1lua(C) : TAAAGVALVVKAAGGSVKGKKAVVLAGTGPVGMRSAALLAGEGAEVVLCG 
           __________________________________________________ 

           __________________________________________________ 
 1lu9(A) : RKLDKAQAAADSVNKRFKVNVTAAETADDASRAEAVKGAHFVFTAGAIGL 
         :                                                    
 1lua(C) : RKLDKAQAAADSVNKRFKVNVTAAETADDASRAEAVKGAHFVFTAGAIGL 
           __________________________________________________ 

           __________________________________________________ 
 1lu9(A) : ELLPQAAWQNESSIEIVADYNAQPPLGIGGIDATDKGKEYGGKRAFGALG 
         :                                                    
 1lua(C) : ELLPQAAWQNESSIEIVADYNAQPPLGIGGIDATDKGKEYGGKRAFGALG 
           __________________________________________________ 

           ___257________________276____________              
 1lu9(A) : IGGLKLKLHRACIAKLFESSEGVFDAEEIYKLAKEMA              
         :                                                    
 1lua(C) : IGGLKLKLHRACIAKLFESSEGVFDAEEIYKLAKEMA              
           ___257________________276____________              

Details

  Property   Value
 Conformer 1 1lu9(A)
 Conformer 2 1lua(C)
 Radius gyration for conformer 1 19.5 A
 Radius gyration for conformer 2 19.72 A
 EC Number 1.5.1.5  
Click here to see the DynDom results or the famliy
 Trigger ligands NAP2456
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact No
 Spanning ligands Yes
 Residues in enzyme contacting ligands ALA127  ALA196  ALA198  ARG152  ASN222  ASN97  GLY130  GLY151  GLY197  ILE199  LEU201  LYS156  LYS256  PRO131  THR102  THR129  TYR221  VAL132 
 Residues in extended bending regions contacting ligands ASN97  LYS256  THR102 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands LYS256 
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT