Phosophoribosylglycinamide formyltransferase
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           _____________14___19___24_________________________ 
 1meo(A) : *ARVAVLISGTGSNLQALIDSTREPNSSAQIDIVISNKAAVAGLDKAERA 
         :                                                    
 1men(C) : RILVAVLISGTGSNLQALIDSTREPNSSAQIDIVISNKAAVAGLDKAERA 
           _____________14___19___24_________________________ 

           __________________________________________________ 
 1meo(A) : GIPTRVINHKLYKNRVEFDSAIDLVLEEFSIDIVCLAGFMRILSGPFVQK 
         :                                                    
 1men(C) : GIPTRVINHKLYKNRVEFDSAIDLVLEEFSIDIVCLAGFMRILSGPFVQK 
           __________________________________________________ 

           __104_______________________________138___________ 
 1meo(A) : WNGKMLNIHPSLLPSFKGSNAHEQALETGVTVTGCTVHFVAE---aGQII 
         :                                                    
 1men(C) : WNGKMLNIHPSLLPSFKGSNAHEQALETGVTVTGCTVHFVAEDVDAGQII 
           __104_______________________________138___________ 

           __________________________________________________ 
 1meo(A) : LQEAVPVKRGDTVATLSERVKLAEHKIFPAALQLVASGTVQLGENGKICW 
         :                                                    
 1men(C) : LQEAVPVKRGDTVATLSERVKLAEHKIFPAALQLVASGTVQLGENGKICW 
           __________________________________________________ 

           ______                                             
 1meo(A) : VKEEHH                                             
         :                                                    
 1men(C) : V*****                                             
           ______                                             

Details

  Property   Value
 Conformer 1 1meo(A)
 Conformer 2 1men(C)
 Radius gyration for conformer 1 16.86 A
 Radius gyration for conformer 2 16.48 A
 EC Number 2.1.2.2  
Click here to see the DynDom results or the famliy
 Trigger ligands GAR225
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact Yes
 Spanning ligands Yes
 Residues in enzyme contacting ligands ASN13  GLU173  GLY11  GLY87  ILE107  LYS170  MET89  PRO109  SER12  THR10 
 Residues in extended bending regions contacting ligands ASN13  GLY11  ILE107  SER12 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands ASN13  GLY11  SER12 
  Residues in extended bending regions with an H-bond between its main chain and ligands ASN13  GLY11  SER12 
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT