Triosephosphate isomerase
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1tim(B) : APRKFFVGGNWKMNGKRKSLGELIHTLDGAKLSADTEVVCGAPSIYLDFA 
         :                                                    
 1ssg(A) : APRKFFVGGNWKMNGDKKSLGELIHTLNGAKLSADTEVVCGAPSIYLDFA 
           __________________________________________________ 

           __________________________________________________ 
 1tim(B) : RQKLDAKIGVAAQNCYKVPKGAFTGEISPAMIKDIGAAWVILGHSERRHV 
         :                                                    
 1ssg(A) : RQKLDAKIGVAAQNCYKVPKGAFTGEISPAMIKDIGAAWVILGHSERRHV 
           __________________________________________________ 

           __________________________________________________ 
 1tim(B) : FGESDELIGQKVAHALAEGLGVIACIGEKLDEREAGITEKVVFQETKAIA 
         :                                                    
 1ssg(A) : FGESDELIGQKVAHALAEGLGVIACIGEKLDEREAGITEKVVFEQTKAIA 
           __________________________________________________ 

           _______161__________________182___________________ 
 1tim(B) : DNVKDWSKVVLAYEPVWAIGTGKTATPQQAQEVHEKLRGWLKTHVSDAVA 
         :                                                    
 1ssg(A) : DNVKDWSKVVLAYEPVWAIGTGYSLTPQQAQEVHEKLRGWLKSHVSDAVA 
           _______161__________________182___________________ 

           _______________________________________________    
 1tim(B) : VQSRIIYGGSVTGGNCKELASQHDVDGFLVGGASLKPEFVDIINAKH    
         :                                                    
 1ssg(A) : QSTRIIYGGSVTGGNCKELASQHDVDGFLVGGASLKPEFVDIINAKH    
           _______________________________________________    

Details

  Property   Value
 Conformer 1 1tim(B)
 Conformer 2 1ssg(A)
 Radius gyration for conformer 1 17.35 A
 Radius gyration for conformer 2 17.04 A
 EC Number 5.3.1.1  
Click here to see the DynDom results or the famliy
 Trigger ligands PGA300
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact Yes
 Spanning ligands Yes
 Residues in enzyme contacting ligands ALA169  ASN11  GLU165  GLY171  GLY210  GLY232  GLY233  HIS95  ILE170  LYS13  SER211 
 Residues in extended bending regions contacting ligands GLU165 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT