Bisphosphoglycerate mutase
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           _______10_________________________________________ 
 1t8p(B) : SKYKLIMLRHGEGAWNKENRFCSWVDQKLNSEGMEEARNCGKQLKALNFE 
         :                                                    
 2hhj(B) : SKYKLIMLRHGEGAWNKENRFCSWVDQKLNSEGMEEARNCGKQLKALNFE 
           _______10_________________________________________ 

           _____________________________________________98___ 
 1t8p(B) : FDLVFTSVLNRSIHTAWLILEELGQEWVPVESSWRLNERHYGALIGLNRE 
         :                                                    
 2hhj(B) : FDLVFTSVLNRSIHTAWLILEELGQEWVPVESSWRLNERHYGALIGLNRE 
           _____________________________________________98___ 

           _________________121______________________________ 
 1t8p(B) : QMALNHGEEQVRLWRRSYNVTPPPIEESHPYYQEIYNDRRYKVCDVPLDQ 
         :                                                    
 2hhj(B) : QMALNHGEEQVRLWRRSYNVTPPPIEESHPYYQEIYNDRRYKVCDVPLDQ 
           _________________121______________________________ 

           __________________________________________________ 
 1t8p(B) : LPRSESLKDVLERLLPYWNERIAPEVLRGKTILISAHGNSSRALLKHLEG 
         :                                                    
 2hhj(B) : LPRSESLKDVLERLLPYWNERIAPEVLRGKTILISAHGNSSRALLKHLEG 
           __________________________________________________ 

           __________________________________________________ 
 1t8p(B) : ISDEDIINITLPTGVPILLELDENLRAVGPHQFLGDQEAIQAAIKKVED* 
         :                                                    
 2hhj(B) : ISDEDIINITLPTGVPILLELDENLRAVGPHQFLGDQEAIQAAIKKVEDQ 
           __________________________________________________ 

           ____                                               
 1t8p(B) : ****                                               
         :                                                    
 2hhj(B) : GKVK                                               
           ____                                               

Details

  Property   Value
 Conformer 1 1t8p(B)
 Conformer 2 2hhj(B)
 Radius gyration for conformer 1 17.62 A
 Radius gyration for conformer 2 17.43 A
 EC Number 5.4.2.4   5.4.2.1   3.1.3.13  
Click here to see the DynDom results or the famliy
 Trigger ligands 3PG3201
PHS1013
DG22200
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact Yes
 Spanning ligands Yes
 Residues in enzyme contacting ligands ARG10  ARG100  ARG116  ARG117  ARG62  ASN17  ASN190  CYS23  GLU89  GLY189  HIS11  HIS188  PHE22  SER24  TYR92 
 Residues in extended bending regions contacting ligands ARG10  ARG100  ASN17  CYS23  HIS11  PHE22  SER24 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands ARG10  ARG100  ASN17  CYS23  HIS11  SER24 
  Residues in extended bending regions with an H-bond between its main chain and ligands CYS23  SER24 
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT