Ketopantoate reductase
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1ks9(A) : MKITVLGCGALGQLWLTALCKQGHEVQGWLRVPQPYCSVNLVETDGSIFN 
         :                                                    
 1yjq(A) : MKITVLGCGALGQLWLTALCKQGHEVQGWLRVPQPYCSVNLVETDGSIFN 
           __________________________________________________ 

           __________________________________________________ 
 1ks9(A) : ESLTANDPDFLATSDLLLVTLKAWQVSDAVKSLASTLPVTTPILLIHNGM 
         :                                                    
 1yjq(A) : ESLTANDPDFLATSDLLLVTLKAWQVSDAVKSLASTLPVTTPILLIHNGM 
           __________________________________________________ 

           __________________________________________________ 
 1ks9(A) : GTIEELQNIQQPLLMGTTTHAARRDGNVIIHVANGITHIGPARQQDGDYS 
         :                                                    
 1yjq(A) : GTIEELQNIQQPLLMGTTTHAARRDGNVIIHVANGITHIGPARQQDGDYS 
           __________________________________________________ 

           _______________________176________________________ 
 1ks9(A) : YLADILQTVLPDVAWHNNIRAELWRKLAVNCVINPLTAIWNCPNGELRHH 
         :                                                    
 1yjq(A) : YLADILQTVLPDVAWHNNIRAELWRKLAVNCVINPLTAIWNCPNGELRHH 
           _______________________176________________________ 

           _____________________________________________248__ 
 1ks9(A) : PQEIMQICEEVAAVIEREGHHTSAEDLRDYVMQVIDATAENISSMLQDIR 
         :                                                    
 1yjq(A) : PQEIMQICEEVAAVIEREGHHTSAEDLRDYVMQVIDATAENISSMLQDIR 
           _____________________________________________248__ 

           _______260_________________________________        
 1ks9(A) : ALRHTEIDYINGFLLRRARAHGIAVPENTRLFEMVKRKESE**        
         :                                                    
 1yjq(A) : ALRHTEIDYINGFLLRRARAHGIAVPENTRLFEMVKRKESEYE        
           _______260_________________________________        

Details

  Property   Value
 Conformer 1 1ks9(A)
 Conformer 2 1yjq(A)
 Radius gyration for conformer 1 19.36 A
 Radius gyration for conformer 2 19.04 A
 EC Number 1.1.1.169  
Click here to see the DynDom results or the famliy
 Trigger ligands MPD601
NAP501
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact Yes
 Spanning ligands No
 Residues in enzyme contacting ligands ALA10  ALA121  ALA122  ALA79  ARG31  ASN98  CYS20  CYS8  GLN75  GLU256  GLU51  GLY23  GLY7  GLY9  HIS120  HIS97  ILE96  LEU11  LEU30  LEU6  LEU71  LYS72  PHE49  THR118  THR70  TRP29 
 Residues in extended bending regions contacting ligands Null
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT