3-deoxy-manno-octulosonate cytidylyltransfera
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1vic(A) : SFTVIIPARFASSRLPGKPLADIKGKPMIQHVFEKALQSGASRVIIATDN 
         :                                                    
 1vh3(B) : SFTVIIPARFA--rLPGKPLADIKGKP-iQHVFEKALQSGASRVIIATDN 
           __________________________________________________ 

           ___________________72_____________________________ 
 1vic(A) : ENVADVAKSFGAEVCMTSVNHNSGTERLAEVVEKLAIPDNEIIVNIQGDE 
         :                                                    
 1vh3(B) : ENVADVAKSFGAEVC-tSVNHNSGTERLAEVVEKLAIPDNEIIVNIQGDE 
           ___________________72_____________________________ 

           ____108___________________________________________ 
 1vic(A) : PLIPPVIVRQVADNLAKFNVNMASLAVKIHDAEELFNPNAVKVLTDKDGY 
         :                                                    
 1vh3(B) : PLIPPVIVRQVADNLAKFNVN-aSLAVKIHDAEELFNPNAVKVLTDKDGY 
           ____108___________________________________________ 

           ___________________________________189_193________ 
 1vic(A) : VLYFSRSVIPYDRDQFMNLQDVQKVQLSDAYLRHIGIYAYRAGFIKQYVQ 
         :                                                    
 1vh3(B) : VLYFSRSVIPYDRDQF-nLQDVQKVQLSDAYLRHIGIYAYRAGFIKQYVQ 
           ___________________________________189_193________ 

           ___________________________231____________________ 
 1vic(A) : WAPTQLENLEKLEQLRVLYNGERIHVELAKEVPAVGVDTAEDLEKVRAIL 
         :                                                    
 1vh3(B) : WAPTQLENLEKLEQLRVLYNGERIHVELAKEVPAVGVDTAEDLEKVRA** 
           ___________________________231____________________ 

           _____                                              
 1vic(A) : AANGS                                              
         :                                                    
 1vh3(B) : *****                                              
           _____                                              

Details

  Property   Value
 Conformer 1 1vic(A)
 Conformer 2 1vh3(B)
 Radius gyration for conformer 1 18.71 A
 Radius gyration for conformer 2 17.89 A
 EC Number 2.7.7.38  
Click here to see the DynDom results or the famliy
 Trigger ligands CMK2
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact Yes
 Spanning ligands Yes
 Residues in enzyme contacting ligands ALA9  ARG10  ARG157  ARG78  ASN73  ASP100  GLN215  GLN98  GLU214  GLY187  GLY75  GLY99  HIS185  HIS72  LEU213  LYS212  PRO8  SER74  TYR189  VAL142 
 Residues in extended bending regions contacting ligands ARG78  ASN73  GLY187  GLY75  HIS72  SER74  TYR189 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands ARG78  HIS72  TYR189 
  Residues in extended bending regions with an H-bond between its main chain and ligands HIS72 
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT