diphosphate--fructose-6-phosphate 1-phosphotr
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 2f48(B) : TSLFKQERQKYIPKLPNILKKDFNNISLVYGENTEAIQDRQALKEFFKNT 
         :                                                    
 2f48(A) : *SLFKQERQKYIPKLPNILKKDFNNISLVYGENTEAIQDRQALKEFFKNT 
           __________________________________________________ 

           __________________________________________________ 
 2f48(B) : YGLPIISFTEGESSLSFSKALNIGIILSGGPAPGGHNVISGVFDAIKKFN 
         :                                                    
 2f48(A) : YGLPIISFTEGESSLSFSKALNIGIILSGGPAPGGHNVISGVFDAIKKFN 
           __________________________________________________ 

           __________________________________________________ 
 2f48(B) : PNSKLFGFKGGPLGLLENDKIELTESLINSYRNTGGFDIVSSGRTKIETE 
         :                                                    
 2f48(A) : PNSKLFGFKGGPLGLLENDKIELTESLINSYRNTGGFDIVSSGRTKIETE 
           __________________________________________________ 

           __________________________________________________ 
 2f48(B) : EHYNKALFVAKENNLNAIIIIGGDDSNTNAAILAEYFKKNGENIQVIGVP 
         :                                                    
 2f48(A) : EHYNKALFVAKENNLNAIIIIGGDDSNTNAAILAEYFKKNGENIQVIGVP 
           __________________________________________________ 

           _____________________________________________250__ 
 2f48(B) : KTIDADLRNDHIEISFGFDSATKIYSELIGNLCRDAMSTKKYWHFVKLMG 
         :                                                    
 2f48(A) : KTIDADLRNDHIEISFGFDSATKIYSELIGNLCRDAMSTKKYWHFVKLMG 
           _____________________________________________250__ 

           __________________________________________________ 
 2f48(B) : RSASHVALECALKTHPNICIVSEEVLAKKKTLSEIIDEMVSVILKRSLNG 
         :                                                    
 2f48(A) : RSASHVALECALKTHPNICIVSEEVLAKKKTLSEIIDEMVSVILKRSLNG 
           __________________________________________________ 

           _______312________________________________________ 
 2f48(B) : DNFGVVIVPEGLIEFIPEVKSLMLELCDIFDKNEGEFKGLNIEKMKEIFV 
         :                                                    
 2f48(A) : DNFGVVIVPEGLIEFIPEVKSLMLELCDIFDKNEGEFKGLNIEKMKEIFV 
           _______312________________________________________ 

           ____________________________383________394________ 
 2f48(B) : AKLSDYMKGVYLSLPLFIQFELIKSILERDPHGNFNVSRVPTEKLFIEMI 
         :                                                    
 2f48(A) : AKLSDYMKGVYLSLPLFIQFELIKSILERDPHGNFNVSRVPTEKLFIEMI 
           ____________________________383________394________ 

           __________________________________________________ 
 2f48(B) : QSRLNDMKKRGEYKGSFTPVDHFFGYEGRSAFPSNFDSDYCYSLGYNAVV 
         :                                                    
 2f48(A) : QSRLNDMKKRGEYKGSFTPVDHFFGYEGRSAFPSNFDSDYCYSLGYNAVV 
           __________________________________________________ 

           __________________________________________________ 
 2f48(B) : LILNGLTGYMSCIKNLNLKPTDWIAGGVPLTMLMNMEERYGEKKPVIKKA 
         :                                                    
 2f48(A) : LILNGLTGYMSCIKNLNLKPTDWIAGGVPLTMLMNMEERYGEKKPVIKKA 
           __________________________________________________ 

           __________________________________________________ 
 2f48(B) : LVDLEGRPFKEFVKNRDKWALNNLYLYPGPVQYFGSSEIVDEITETLKLE 
         :                                                    
 2f48(A) : LVDLEGRPFKEFVKNRDKWALNNLYLYPGPVQYFGSSEIVDEITETLKLE 
           __________________________________________________ 

           __                                                 
 2f48(B) : LF                                                 
         :                                                    
 2f48(A) : LF                                                 
           __                                                 

Details

  Property   Value
 Conformer 1 2f48(B)
 Conformer 2 2f48(A)
 Radius gyration for conformer 1 26.02 A
 Radius gyration for conformer 2 24.87 A
 EC Number 2.7.1.90  
Click here to see the DynDom results or the famliy
 Trigger ligands BFP829
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact Yes
 Spanning ligands Yes
 Residues in enzyme contacting ligands ARG146  ARG253  ARG431  ASP206  GLU312  GLY252  GLY81  GLY82  ILE205  LYS203  MET251  SER390  THR204  TYR428 
 Residues in extended bending regions contacting ligands ARG253  GLU312  GLY252  MET251  SER390 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands ARG253  GLU312  GLY252  SER390 
  Residues in extended bending regions with an H-bond between its main chain and ligands GLY252 
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT