Hypothetical protein Rv1264/MT1302
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1y11(A) : DDLLGDLGGTARAERAKLVEWLLEQGITPDEIRATNPPLLLATRHLVGDD 
         :                                                    
 1y10(B) : ******LGGTARAERAKLVEWLLEQGITPDEIRATNPPLLLATRHLVGDD 
           __________________________________________________ 

           __________________________________________________ 
 1y11(A) : GTYVSAREISENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAAR 
         :                                                    
 1y10(B) : GTYVSAREISENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAAR 
           __________________________________________________ 

           __________________________________________________ 
 1y11(A) : AQRFVELGLNPDQVVLVVRVLAEGLSHAAEAMRYTALEAIMRPGATELDI 
         :                                                    
 1y10(B) : AQRFVELGLNPDQVVLVVRVLAEGLSHAAEAMRYTALEAIMRPGATELDI 
           __________________________________________________ 

           ______________________________196_________________ 
 1y11(A) : AKGSQALVSQIVPLLGPMIQDMLFMQLRHMMETEAVNAGERAAGKPLPGA 
         :                                                    
 1y10(B) : AKGSQALVSQIVPLLGPMIQDMLFMQLRHMMETEAVNAGERAAGKPLPGA 
           ______________________________196_________________ 

           __________________________________________________ 
 1y11(A) : RQVTVAFADLVGFTQLGEVVSAEELGHLAGRLAGLARDLTAPPVWFIKTI 
         :                                                    
 1y10(B) : RQVTVAFADLVGFTQLGEVVSAEELGHLAGRLAGLARDLTAPPVWFIKTI 
           __________________________________________________ 

           __________________________________________________ 
 1y11(A) : GDAVMLVCPDPAPLLDTVLKLVEVVDTDNNFPRLRAGVASGMAVSRAGDW 
         :                                                    
 1y10(B) : GDAVMLVCPDPAPLLDTVLKLVEVVDTDNNFPRLRAGVASGMAVSRAGDW 
           __________________________________________________ 

           __________________________________________________ 
 1y11(A) : FGSPVNVASRVTGVARPGAVLVADSVREALGDAPEADGFQWSFAGPRRLR 
         :                                                    
 1y10(B) : FGSPVNVASRVTGVARPGAVLVADSVREALGDAPEADGFQWSFAGPRRLR 
           __________________________________________________ 

           ______________                                     
 1y11(A) : GIRGDVRLFRVRRG                                     
         :                                                    
 1y10(B) : GIRGDVRLFRVRR*                                     
           ______________                                     

Details

  Property   Value
 Conformer 1 1y11(A)
 Conformer 2 1y10(B)
 Radius gyration for conformer 1 26.09 A
 Radius gyration for conformer 2 26.5 A
 EC Number 4.6.1.1  
Click here to see the DynDom results or the famliy
 Trigger ligands GOL2
 Trigger ligands in which conformation Conformation  1
 Conformaton with trigger ligands is compact Yes
 Spanning ligands No
 Residues in enzyme contacting ligands ARG296  ARG329  GLY331 
 Residues in extended bending regions contacting ligands Null
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT