mRNA capping enzyme alpha subunit
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           ____6_____________________________________________ 
 1p16(A) : VQLEEREIPVIPGNKLDEEETKELRLvAELLGRRNTGFPGSQPVSFERRH 
         :                                                    
 1p16(B) : VQLEEREIPVIPGNKLDEEETKELRLvAELLGRRNTGFPGSQPVSFERRH 
           ____6_____________________________________________ 

           __________________________________________________ 
 1p16(A) : LEETLqKDYFVCEKTDGLRCLLFLINDPDKGEGVFLVTRENDYYFIPNIH 
         :                                                    
 1p16(B) : LEETLqKDYFVCEKTDGLRCLLFLINDPDKGEGVFLVTRENDYYFIPNIH 
           __________________________________________________ 

           __________________________________________________ 
 1p16(A) : FPLSVNETREKPTYHHGTLLDGELVLENRNVSEPVLRYVIFDALAIHGKC 
         :                                                    
 1p16(B) : FPLSVNETREKPTYHHGTLLDGELVLENRNVSEPVLRYVIFDALAIHGKC 
           __________________________________________________ 

           __________________________________________________ 
 1p16(A) : IIDRPLPKRLGYITENVkPFDNFKKHNPDIVNSPEFPFKVGFKTlTSYHA 
         :                                                    
 1p16(B) : IIDRPLPKRLGYITENVkPFDNFKKHNPDIVNSPEFPFKVGFKTlTSYHA 
           __________________________________________________ 

           ___________________________________244____________ 
 1p16(A) : DDVLSKdKLFHASDGLIYTCAETPYVFGTDQTLLKWKPAEENTVDFQLEF 
         :                                                    
 1p16(B) : DDVLSKdKLFHASDGLIYTCAETPYVFGTDQTLLKWKPAEENTVDFQLEF 
           ___________________________________244____________ 

           __________________________________________________ 
 1p16(A) : VFNEVQDPDLDERDPTSTYLDYDAKPNLIKLRVWQGSNVHTDFAKLDLSD 
         :                                                    
 1p16(B) : VFNEVQ------------yLDYDAKPNLIKLRVWQGSNVHTDFAKLDLSD 
           __________________________________________________ 

           __________________________________________________ 
 1p16(A) : DDWERLKALEQPLQGRIAECRQSTTKKGYWElRFRNDKSNGNHISVVEKI 
         :                                                    
 1p16(B) : DDWERLKALEQPLQGRIAECRQSTTKKGYWElRFRNDKSNGNHISVVEKI 
           __________________________________________________ 

           __362____________________________                  
 1p16(A) : LVSIKDGVKEKEVIEWCPKISRAWKKRENDRRQ                  
         :                                                    
 1p16(B) : LVSIKDGVKEKEVIEWCPKISRAWKKRENDRR*                  
           __362____________________________                  

Details

  Property   Value
 Conformer 1 1p16(A)
 Conformer 2 1p16(B)
 Radius gyration for conformer 1 24.62 A
 Radius gyration for conformer 2 24.77 A
 EC Number 2.7.7.50  
Click here to see the DynDom results or the famliy
 Trigger ligands GTP5001
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact No
 Spanning ligands No
 Residues in enzyme contacting ligands ARG72  CYS65  GLN44  GLU126  ILE223  LEU239  LYS197  LYS241  LYS243  LYS67  PHE144  PRO45  SER43 
 Residues in extended bending regions contacting ligands LYS241  LYS243 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands LYS241  LYS243 
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT