phosphoglycerate kinase
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1kf0(A) : SLSNKLTLDKLNVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCL 
         :                                                    
 1vjc(A) : SLSNKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAIPSIKFCL 
           __________________________________________________ 

           __________________________________________________ 
 1kf0(A) : DDGAKSVVLMSHLGRPDGSPMPDKYSLQPVAVELKSLLGKDVLFLKDCVG 
         :                                                    
 1vjc(A) : DNGAKSVVLMSHLGRPDGIPMPDKYSLEPVAVELKSLLGKDVLFLKDCVG 
           __________________________________________________ 

           ____________________123_________________143_______ 
 1kf0(A) : PEVEKACADPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIKTFR 
         :                                                    
 1vjc(A) : PEVEKACADPAAGSVILLENLRFHVEEEGKGKDASGSKVKADPAKIEAFR 
           ____________________123_________________143_______ 

           _________162___________176________187_____________ 
 1kf0(A) : ASLSKLGDVYVNDAFGTAHRAHSSMVGVNLPKKAGGFLMKKELNYFAKAL 
         :                                                    
 1vjc(A) : ASLSKLGDVYVNDAFGTAHRAHSSMVGVNLPKKAGGFLMKKELNYFAKAL 
           _________162___________176________187_____________ 

           __________________________________________________ 
 1kf0(A) : ESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMAFTFLKVLNNM 
         :                                                    
 1vjc(A) : ESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMAFTFLKVLNNM 
           __________________________________________________ 

           __________________________________________________ 
 1kf0(A) : EIGTSLFDEEGAKIVKNLMSKAEKNGVKITLPVDFVTADKFDEHAKTGQA 
         :                                                    
 1vjc(A) : EIGTSLFDEEGSKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQA 
           __________________________________________________ 

           __________________________________________________ 
 1kf0(A) : TVASGIPAGWMGLDCGPESSKKYSEAVARAKQIVWNGPVGVFEWEAFAQG 
         :                                                    
 1vjc(A) : TVASGIPAGWMGLDCGPESSKKYSEAVARAKQIVWNGPVGVFEWEAFAQG 
           __________________________________________________ 

           __________________________________________________ 
 1kf0(A) : TKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGASLE 
         :                                                    
 1vjc(A) : TKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGASLE 
           __________________________________________________ 

           ____407_________                                   
 1kf0(A) : LLEGKVLPGVDALSNV                                   
         :                                                    
 1vjc(A) : LLEGKVLPGVDALSNV                                   
           ____407_________                                   

Details

  Property   Value
 Conformer 1 1kf0(A)
 Conformer 2 1vjc(A)
 Radius gyration for conformer 1 23.5 A
 Radius gyration for conformer 2 23.25 A
 EC Number 2.7.2.3  
Click here to see the DynDom results or the famliy
 Trigger ligands MP3417
 Trigger ligands in which conformation Conformation  1
 Conformaton with trigger ligands is compact No
 Spanning ligands Yes
 Residues in enzyme contacting ligands ARG122  ARG170  ARG38  ARG65  ASN25  ASP23  GLY166  HIS62 
 Residues in extended bending regions contacting ligands ARG122  GLY166 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands ARG122 
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT