Phospho-2-dehydro-3-deoxyheptonate aldolase
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1rzm(B) : *****MIVVLKPGSTEEDIRKVVKLAESYNLKCHISKGQERTVIGIIGDD 
         :                                                    
 1vr6(A) : HHHHHMIVVLKPGSTEEDIRKVVKLAESYNLKCHISKGQERTVIGIIGDD 
           __________________________________________________ 

           __________________65______________________________ 
 1rzm(B) : RYVVADKFESLDCVESVVRVLKPYKLVSREFHPEDTVIDLGDVKIGNGYF 
         :                                                    
 1vr6(A) : RYVVADKFESLDCVESVVRVLKPYKLVSREFHPEDTVIDLGDVKIGNGYF 
           __________________65______________________________ 

           __________________________________________________ 
 1rzm(B) : TIIAGPCSVEGREMLMETAHFLSELGVKVLRGGAYKPRTSPYSFQGLGEK 
         :                                                    
 1vr6(A) : TIIAGPCSVEGREMLMETAHFLSELGVKVLRGGAYKPRTSPYSFQGLGEK 
           __________________________________________________ 

           __________________________________________________ 
 1rzm(B) : GLEYLREAADKYGMYVVTEALGEDDLPKVAEYADIIQIGARNAQNFRLLS 
         :                                                    
 1vr6(A) : GLEYLREAADKYGMYVVTEALGEDDLPKVAEYADIIQIGARNAQNFRLLS 
           __________________________________________________ 

           __________________________________________________ 
 1rzm(B) : KAGSYNKPVLLKRGFMNTIEEFLLSAEYIANSGNTKIILCERGIRTFEKA 
         :                                                    
 1vr6(A) : KAGSYNKPVLLKRGFMNTIEEFLLSAEYIANSGNTKIILCERGIRTFEKA 
           __________________________________________________ 

           __________________________________________________ 
 1rzm(B) : TRNTLDISAVPIIRKESHLPILVDPSHSGGRRDLVIPLSRAAIAVGAHGI 
         :                                                    
 1vr6(A) : TRNTLDISAVPIIRKESHLPILVDPSHSGGRRDLVIPLSRAAIAVGAHGI 
           __________________________________________________ 

           ___________________________________________        
 1rzm(B) : IVEVHPEPEKALSDGKQSLDFELFKELVQEMKKLADALGVKVN        
         :                                                    
 1vr6(A) : IVEVHPEPEKALSDGKQSLDFELFKELVQEMKKLADALGVKVN        
           ___________________________________________        

Details

  Property   Value
 Conformer 1 1rzm(B)
 Conformer 2 1vr6(A)
 Radius gyration for conformer 1 21.52 A
 Radius gyration for conformer 2 23.49 A
 EC Number 2.5.1.54  
Click here to see the DynDom results or the famliy
 Trigger ligands E4P9003
CD9001
CD9009
PEP9002
 Trigger ligands in which conformation Conformation  1
 Conformaton with trigger ligands is compact Yes
 Spanning ligands No
 Residues in enzyme contacting ligands ALA185  ARG126  ARG133  ARG186  ARG237  ARG247  ASP309  CYS102  GLN182  GLN312  GLU119  GLU164  GLU298  GLY184  HIS115  HIS272  LYS131  LYS207  PRO132  SER308  THR134 
 Residues in extended bending regions contacting ligands Null
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT