tyrosyl-tRNA synthetase
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1n3l(A) : APSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYF 
         :                                                    
 1q11(A) : APSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYF 
           __________________________________________________ 

           __________________73___________________94_________ 
 1n3l(A) : VPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRVSYYENVIKA 
         :                                                    
 1q11(A) : VPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRVSYYENVIKA 
           __________________73___________________94_________ 

           __________________________________________________ 
 1n3l(A) : MLESIGVPLEKLKFIKGTDYQLSKEYTLDVYRLSSVVTQHDSKKAGAEVV 
         :                                                    
 1q11(A) : MLESIGVPLEKLKFIKGTDYQLSKEYTLDVYRLSSVVTQHDSKKAGAEVV 
           __________________________________________________ 

           __________________________________________________ 
 1n3l(A) : KQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGIDQRKIFTFAEKYLPALG 
         :                                                    
 1q11(A) : KQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGIDQRKIFTFAEKYLPALG 
           __________________________________________________ 

           __________________________________________________ 
 1n3l(A) : YSKRVHLMNPMVPGLTGSeSKIDLLDRKEDVKKKLKKAFCEPGNVENNGV 
         :                                                    
 1q11(A) : YSKRVHLMNPMVPGLTG---kIDLLDRKEDVKKKLKKAFCEPGNVENNGV 
           __________________________________________________ 

           __________________________________________________ 
 1n3l(A) : LSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFAAEVVHPGDLK 
         :                                                    
 1q11(A) : LSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFAAEVVHPGDLK 
           __________________________________________________ 

           ______________327_______________                   
 1n3l(A) : NSVEVALNKLLDPIREKFNTPALKKLASAAYP                   
         :                                                    
 1q11(A) : NSVEVALNKLLDPIREKFNTPALKKLASAAYP                   
           ______________327_______________                   

Details

  Property   Value
 Conformer 1 1n3l(A)
 Conformer 2 1q11(A)
 Radius gyration for conformer 1 21.19 A
 Radius gyration for conformer 2 21 A
 EC Number 6.1.1.1  
Click here to see the DynDom results or the famliy
 Trigger ligands TYB401
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact Yes
 Spanning ligands Yes
 Residues in enzyme contacting ligands ALA43  ALA74  ASP173  GLN170  GLN182  GLN188  GLY41  HIS77  LEU72  TYR166  TYR39  VAL152 
 Residues in extended bending regions contacting ligands ALA74  HIS77  LEU72 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT