ARGININOSUCCINATE SYNTHASE
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1kp3(A) : TTILKHLPVGQRIGIAFSGGLDTSAALLWMRQKGAVPYAYTANLGQPDEE 
         :                                                    
 1k92(A) : TTILKHLPVGQRIGIAFSGGLDTSAALLWMRQKGAVPYAYTANLGQPDEE 
           __________________________________________________ 

           __________________________________________________ 
 1kp3(A) : DYDAIPRRAMEYGAENARLIDCRKQLVAEGIAAIQCGAFHNTTGGLTYFN 
         :                                                    
 1k92(A) : DYDAIPRRAMEYGAENARLIDCRKQLVAEGIAAIQCGAFHNTTGGLTYFN 
           __________________________________________________ 

           _____________116___122___________________________1 
 1kp3(A) : TTPLGRAVTGTMLVAAMKEDGVNIWGDGSTYKGNDIERFYRYGLLTNAEL 
         :                                                    
 1k92(A) : TTPLGRAVTGTMLVAAMKEDGVNIWGDGSTYKGNDIERFYRYGLLTNAEL 
           _____________116___122___________________________1 

           52____________167_________________________________ 
 1kp3(A) : QIYKPWLDTDFIDELGGRHEMSEFMIACGFDYKMSVEKAYSTDSNMLGAT 
         :                                                    
 1k92(A) : QIYKPWLDTDFIDELGGRHEMSEFMIACGFDYKMSVEKAYSTDSNMLGAT 
           52____________167_________________________________ 

           __________________________________________________ 
 1kp3(A) : HEAKDLEYLNSSVKIVNPIMGVKFWDESVKIPAEEVTVRFEQGHPVALNG 
         :                                                    
 1k92(A) : HEAKDLEYLNSSVKIVNPIMGVKFWDESVKIPAEEVTVRFEQGHPVALNG 
           __________________________________________________ 

           __________________________________________________ 
 1kp3(A) : KTFSDDVEMMLEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGMALLH 
         :                                                    
 1k92(A) : KTFSDDVEMMLEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGMALLH 
           __________________________________________________ 

           __________________________________________________ 
 1kp3(A) : IAYERLLTGIHNEDTIEQYHAHGRQLGRLLYQGRWFDSQALMLRDSLQRW 
         :                                                    
 1k92(A) : IAYERLLTGIHNEDTIEQYHAHGRQLGRLLYQGRWFDSQALMLRDSLQRW 
           __________________________________________________ 

           __________________________________________________ 
 1kp3(A) : VASQITGEVTLELRRGNDYSILNTVSENLTYKPER-------sVFSPDDR 
         :                                                    
 1k92(A) : VASQITGEVTLELRRGNDYSILNTVSENLTYKPERLTMEKGDSVFSPDDR 
           __________________________________________________ 

           ______________________________________________     
 1kp3(A) : IGQLTMRNLDITDTREKLFGYAKTGLLSSSAASGVPQVENLENKGQ     
         :                                                    
 1k92(A) : IGQLTMRNLDITDTREKLFGYAKTGLLSSSAASGVPQVENLENK**     
           ______________________________________________     

Details

  Property   Value
 Conformer 1 1kp3(A)
 Conformer 2 1k92(A)
 Radius gyration for conformer 1 26.36 A
 Radius gyration for conformer 2 26.53 A
 EC Number 6.3.4.5  
Click here to see the DynDom results or the famliy
 Trigger ligands ATP301
 Trigger ligands in which conformation Conformation  1
 Conformaton with trigger ligands is compact Yes
 Spanning ligands Yes
 Residues in enzyme contacting ligands ALA16  ALA42  ARG106  ARG168  ASP127  ASP193  ASP22  GLY128  GLY20  LEU113  LEU21  LEU44  PHE139  PHE17  SER129  SER18  THR23  THR41  TYR40 
 Residues in extended bending regions contacting ligands ARG168  ASP127  GLY128  LEU113  SER129 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands GLY128 
  Residues in extended bending regions with an H-bond between its main chain and ligands GLY128 
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT