Creatine kinase, M chain
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1u6r(B) : PFGNTHNKYKLNYKSEEEYPDLSKHNNHMAKVLTPDLYKKLRDKETPSGF 
         :                                                    
 1u6r(A) : PFGNTHNKYKLNYKSEEEYPDLSKHNNHMAKVLTPDLYKKLRDKETPSGF 
           __________________________________________________ 

           __________________________________________________ 
 1u6r(B) : TLDDVIQTGVDNPGHPFIMTVGCVAGDEESYTVFKDLFDPIIQDRHGGFK 
         :                                                    
 1u6r(A) : TLDDVIQTGVDNPGHPFIMTVGCVAGDEESYTVFKDLFDPIIQDRHGGFK 
           __________________________________________________ 

           103_________________________131___________________ 
 1u6r(B) : PTDKHKTDLNHENLKGGDDLDPHYVLSSRVRTGKSIKGYTLPPHCSRGER 
         :                                                    
 1u6r(A) : PTDKHKTDLNHENLKGGDDLDPHYVLSSRVRTGKSIKGYTLPPHCSRGER 
           103_________________________131___________________ 

           _______________________176____________191_________ 
 1u6r(B) : RAVEKLSVEALNSLTGEFKGKYYPLKSMTEQEQQQLIDDHFLFDKPVSPL 
         :                                                    
 1u6r(A) : RAVEKLSVEALNSLTGEFKGKYYPLKSMTEQEQQQLIDDHFLFDKPVSPL 
           _______________________176____________191_________ 

           _______________218__223___________237_____________ 
 1u6r(B) : LLASGMARDWPDARGIWHNDNKSFLVWVNEEDHLRVISMEKGGNMKEVFR 
         :                                                    
 1u6r(A) : LLASGMARDWPDARGIWHNDNKSFLVWVNEEDHLRVISMEKGGNMKEVFR 
           _______________218__223___________237_____________ 

           _254_______________________________288____________ 
 1u6r(B) : RFCVGLQKIEEIFKKAGHPFMWNEHLGYVLTCPSNLGTGLRGGVHVKLAH 
         :                                                    
 1u6r(A) : RFCVGLQKIEEIFKKAGHPFMWNEHLGYVLTCPSNLGTGLRGGVHVKLAH 
           _254_______________________________288____________ 

           __________________________________________________ 
 1u6r(B) : LSKHPKFEEILTRLRLQKRGTGGVDTAAVGSVFDISNADRLGSSEVEQVQ 
         :                                                    
 1u6r(A) : LSKHPKFEEILTRLRLQKRGTGGVDTAAVGSVFDISNADRLGSSEVEQVQ 
           __________________________________________________ 

           ______________________________                     
 1u6r(B) : LVVDGVKLMVEMEKKLEKGQSIDDMIPAQK                     
         :                                                    
 1u6r(A) : LVVDGVKLMVEMEKKLEKGQSIDDMIPAQK                     
           ______________________________                     

Details

  Property   Value
 Conformer 1 1u6r(B)
 Conformer 2 1u6r(A)
 Radius gyration for conformer 1 21.01 A
 Radius gyration for conformer 2 21.93 A
 EC Number 2.7.3.2  
Click here to see the DynDom results or the famliy
 Trigger ligands IOM1601
 Trigger ligands in which conformation Conformation  1
 Conformaton with trigger ligands is compact Yes
 Spanning ligands Yes
 Residues in enzyme contacting ligands ASN285  CYS282  GLU231  ILE68  LEU200  SER284  THR70  VAL324  VAL71 
 Residues in extended bending regions contacting ligands ASN285 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT