Cytochrome P450 2B4
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1suo(A) : GKLPPGPSPLPVLGNLLQMDRKGLLRSFLRLREKYGDVFTVYLGSRPVVV 
         :                                                    
 2bdm(A) : GKLPPGPSPLPVLGNLLQMDRKGLLRSFLRLREKYGDVFTVYLGSRPVVV 
           __________________________________________________ 

           ____________________99____________________________ 
 1suo(A) : LCGTDAIREALVDQAEAFSGRGKIAVVDPIFQGYGVIFANGERWRALRRF 
         :                                                    
 2bdm(A) : LCGTDAIREALVDQAEAFSGRGKIAVVDPIFQGYGVIFANGERWRALRRF 
           ____________________99____________________________ 

           ______136_________________________________________ 
 1suo(A) : SLATMRDFGMGKRSVEERIQEEARCLVEELRKSKGALLDNTLLFHSITSN 
         :                                                    
 2bdm(A) : SLATMRDFGMGKRSVEERIQEEARCLVEELRKSKGALLDNTLLFHSITSN 
           ______136_________________________________________ 

           __________________________________________________ 
 1suo(A) : IICSIVFGKRFDYKDPVFLRLLDLFFQSFSLISSFSSQVFELFSGFLKYF 
         :                                                    
 2bdm(A) : IICSIVFGKRFDYKDPVFLRLLDLFFQSFSLISSFSSQVFELFSGFLKYF 
           __________________________________________________ 

           __________________________________________________ 
 1suo(A) : PGTHRQIYRNLQEINTFIGQSVEKHRATLDPSNPRDFIDVYLLRMEKDKS 
         :                                                    
 2bdm(A) : PGTHRQIYRNLQEINTFIGQSVEKHRATLDPSNPRDFIDVYLLRMEKDKS 
           __________________________________________________ 

           __________________________________________________ 
 1suo(A) : DPSSEFHHQNLILTVLSLFFAGTETTSTTLRYGFLLMLKYPHVTERVQKE 
         :                                                    
 2bdm(A) : DPSSEFHHQNLILTVLSLFFAGTETTSTTLRYGFLLMLKYPHVTERVQKE 
           __________________________________________________ 

           __________________________________________________ 
 1suo(A) : IEQVIGSHRPPALDDRAKMPYTDAVIHEIQRLGDLIPFGVPHTVTKDTQF 
         :                                                    
 2bdm(A) : IEQVIGSHRPPALDDRAKMPYTDAVIHEIQRLGDLIPFGVPHTVTKDTQF 
           __________________________________________________ 

           __________________________________________________ 
 1suo(A) : RGYVIPKNTEVFPVLSSALHDPRYFETPNTFNPGHFLDANGALKRNEGFM 
         :                                                    
 2bdm(A) : RGYVIPKNTEVFPVLSSALHDPRYFETPNTFNPGHFLDANGALKRNEGFM 
           __________________________________________________ 

           __________________________________________________ 
 1suo(A) : PFSLGKRICLGEGIARTELFLFFTTILQNFSIASPVPPEDIDLTPRESGV 
         :                                                    
 2bdm(A) : PFSLGKRICLGEGIARTELFLFFTTILQNFSIASPVPPEDIDLTPRESGV 
           __________________________________________________ 

           _______________                                    
 1suo(A) : GNVPPSYQIRFLARH                                    
         :                                                    
 2bdm(A) : GNVPPSYQIRFLARH                                    
           _______________                                    

Details

  Property   Value
 Conformer 1 1suo(A)
 Conformer 2 2bdm(A)
 Radius gyration for conformer 1 22.42 A
 Radius gyration for conformer 2 24.01 A
 EC Number 1.14.14.1  
Click here to see the DynDom results or the famliy
 Trigger ligands HEM500
 Trigger ligands in which conformation Conformation  1
 Conformaton with trigger ligands is compact Yes
 Spanning ligands Yes
 Residues in enzyme contacting ligands ALA298  ALA442  ARG125  ARG434  ARG98  CYS436  GLN357  GLY299  GLY438  HIS369  ILE114  ILE179  ILE363  ILE441  LEU392  LEU437  PHE429  PRO428  SER430  THR302  THR303  THR306  TRP121  VAL113  VAL367 
 Residues in extended bending regions contacting ligands ARG98  ILE114  VAL113 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands ARG98 
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT