Maltose/maltodextrin import ATP-binding prote
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           ____________________________31___36_______________ 
 1q1e(A) : **VQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAG 
         :                                                    
 2awn(C) : ASVQLQNVT-------vSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAG 
           ____________________________31___36_______________ 

           __________________________________________________ 
 1q1e(A) : LETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLK 
         :                                                    
 2awn(C) : L-----------------------gVGMVFQSYALYPHLSVAENMSFGLK 
           __________________________________________________ 

           __________________________________________________ 
 1q1e(A) : LAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAE 
         :                                                    
 2awn(C) : LAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAE 
           __________________________________________________ 

           _____159________170_______________188_____________ 
 1q1e(A) : PSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLA 
         :                                                    
 2awn(C) : PSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLA 
           _____159________170_______________188_____________ 

           __206____213______________________________________ 
 1q1e(A) : DKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAI 
         :                                                    
 2awn(C) : DKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAI 
           __206____213______________________________________ 

           __________________________________________________ 
 1q1e(A) : DQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILE 
         :                                                    
 2awn(C) : DQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILE 
           __________________________________________________ 

           __________________________________________________ 
 1q1e(A) : GEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPER 
         :                                                    
 2awn(C) : GEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPER 
           __________________________________________________ 

           ________________________                           
 1q1e(A) : CHLFREDGTACRRLHKEPG*****                           
         :                                                    
 2awn(C) : CHLFREDGTACRRLHKEPGVASAS                           
           ________________________                           

Details

  Property   Value
 Conformer 1 1q1e(A)
 Conformer 2 2awn(C)
 Radius gyration for conformer 1 25.26 A
 Radius gyration for conformer 2 24.39 A
 EC Number 3.6.3.19  
Click here to see the DynDom results or the famliy
 Trigger ligands ADP403
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact Yes
 Spanning ligands No
 Residues in enzyme contacting ligands CYS40  GLY39  GLY41  LYS42  SER43  THR44  VAL18 
 Residues in extended bending regions contacting ligands CYS40  GLY39 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands GLY39 
  Residues in extended bending regions with an H-bond between its main chain and ligands GLY39 
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT