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Domain Movement Classification: 'Hinge and Shear'
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Domain Movement Classification using Dynamic Contact Graphs
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Domain Movement in large biomolecular complexes
DynDom3D

Domain Movement in large biomolecular complexes
DynDom3D

  Ligand-induced domain movements in enzymes

 Currently there are  203 domain movements in enzymes with trigger ligands in the database. 150 of them with spaning trigger ligands and 53 of them with non-spanning trigger ligands. For details please see G.Qi, S.Hayward, "Database of ligand-induced domain movements in enzymes",BMC Structural Biology, 9:13, 2009.

Enzyme Name Conformation 1 Conformation 2 Trigger Spanning Ligands Compact Liganded Conf. EC Numbers Details
2-C-methyl-D-erythritol 2,4-cyclodiphosphate 1h48( E) 1h47( E) true false 4.6.1.12  details
2-C-methyl-D-erythritol 2,4-cyclodiphosphate 1h48( E) 1h47( C) true false 4.6.1.12  details
3-dehydroquinate synthase 1xah( A) 1xag( A) true true 4.2.3.4  details
3-DEHYDROQUINATE SYNTHASE 1sg6( B) 1dqs( B) true true 4.2.3.4  4.6.1.3  details
3-deoxy-manno-octulosonate cytidylyltransfera 1vic( A) 1vh3( B) true true 2.7.7.38  details
3-DEOXY-MANNO-OCTULOSONATE CYTIDYLYLTRANSFERA 1gqc( A) 1h7h( B) true true 2.7.7.38  details
3-PHOSPHOGLYCERATE KINASE 16pk( ) 13pk( C) true true 2.7.2.3  details
4-DIPHOSPHOCYTIDYL-2-C-METHYLERYTHRITOL SYNTH 1ini( A) 1vgt( A) true true 2.7.7.60  details
5-enolpyruvylshikimate-3-phosphate synthase 1rf6( C) 1rf5( B) true true 2.5.1.19  details
a2,3-sialyltransferase, a2,6-sialyltransferas 2c83( A) 2ex1( A) true true 2.4.99.4  2.4.99.6  2.4.99.9  details
acetaldehyde dehydrogenase (acylating) 1nvm( F) 1nvm( B) true true 1.2.1.10  details
Acetate kinase 1tuu( A) 1g99( B) true true 2.7.2.1  details
adenosine kinase 1lii( A) 2abs( A) true true 2.7.1.20  details
Adenosine kinase 2i6b( A) 1bx4( A) true true 2.7.1.20  details
ADP-ribosyl cyclase 1 2o3s( B) 2i67( B) true true 3.2.2.5  details
ALCOHOL DEHYDROGENASE 1n8k( A) 1ye3( A) true true 1.1.1.1  details
alcohol dehydrogenase, iron-containing 1o2d( B) 1o2d( A) true true 1.1.1.1  details
Aldo-keto reductase family 1 member C2 1xjb( A) 1j96( A) true false 1.1.1.213  details
Alpha-ketoglutarate-dependent taurine dioxyge 1otj( D) 1otj( C) true true 1.14.11.17  details
ALPHA-TREHALOSE-PHOSPHATE SYNTHASE 1gz5( C) 1uqt( B) true true 2.4.1.15  details
Anthranilate phosphoribosyltransferase 1gxb( C) 1o17( A) false true 2.4.2.18.  2.4.2.18  details
ANTHRANILATE SYNTHASE 1i7s( C) 1i7q( A) false true 4.1.3.27  details
Arginine kinase 1m15( A) 1m80( A) true true 2.7.3.3.  2.7.3.3  details
ARGININOSUCCINATE SYNTHASE 1kp3( A) 1k92( A) true true 6.3.4.5  details
Aristolochene synthase 2oa6( D) 2e4o( B) true true 4.2.3.9  details
AROMATIC AMINO ACID AMINOTRANSFERASE 2ay6( A) 1ay5( B) true true 2.6.1.57  details
aspartate aminotransferase 1j32( A) 1j32( B) false true 2.6.1.1  details
ASPARTATE AMINOTRANSFERASE 1ix8( A) 1toi( A) false false 2.6.1.1  details
ASPARTATE AMINOTRANSFERASE 1akb( A) 7aat( B) false false 2.6.1.1  details
Aspartate beta-semialdehyde dehydrogenase 2gz1( B) 2gyy( B) true true 1.2.1.11  details
ASPARTYL-TRNA SYNTHETASE 1c0a( A) 1il2( A) false true 6.1.1.12  details
ASPARTYL-TRNA SYNTHETASE 1g51( B) 1efw( A) false true 6.1.1.12  details
ASPARTYL-TRNA SYNTHETASE 1eqr( B) 1c0a( A) false true 6.1.1.12  details
ATP synthase beta chain, mitochondrial 2hld( N) 2hld( M) true false 3.6.3.14  details
autocrine motility factor 1jlh( C) 1g98( A) false true 5.3.1.9  details
beta-phosphoglucomutase 1lvh( B) 1z4o( B) true true 5.4.2.6  details
beta-phosphoglucomutase 1z4o( B) 1o08( A) true false 5.4.2.6  details
Bifunctional 3'-phosphoadenosine 5'-phosphosu 1x6v( A) 1x6v( B) false false 2.7.7.4  2.7.1.25  details
Bifunctional P-450 1jpz( B) 1bvy( A) false false 1.14.14.1  details
Bifunctional purine biosynthesis protein PURH 1pkx( D) 1pl0( A) true true 2.1.2.3  3.5.4.10  details
Bisphosphoglycerate mutase 1t8p( B) 2hhj( B) true true 5.4.2.4  5.4.2.1  3.1.3.13  details
CARBON MONOXIDE DEHYDROGENASE ALPHA SUBUNIT 1oao( D) 1mjg( N) true true 1.2.99.2  details
CCA-adding enzyme 1tfy( D) 2dra( A) true true 2.7.7.25  2.7.7.21  details
CCA-adding enzyme 1tfy( D) 1tfw( A) true true 2.7.7.25  details
CDP-glucose 4,6-dehydratase 1wvg( A) 1wvg( B) true true 4.2.1.45  details
Chorismate mutase 2fp2( B) 2ao2( B) true true 5.4.99.5  details
Chorismate synthase 1qxo( A) 1qxo( B) true true 4.2.3.5  details
Coproporphyrinogen III oxidase 1txn( A) 1tlb( Q) false false 1.3.3.3  details
CREATINE KINASE 1crk( B) 2gl6( E) true true 2.7.3.2  details
Creatine kinase, M chain 1u6r( B) 1u6r( A) true true 2.7.3.2  details
CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE 1kph( D) 1kp9( B) false true 2.1.1.79  details
CYTIDYLATE KINASE 1kdt( B) 2cmk( A) true false 2.7.4.14  details
Cytochrome P450 2B4 1suo( A) 2bdm( A) true true 1.14.14.1  details
Cytochrome P450-cam 1k2o( A) 2frz( B) true false 1.14.15.1  details
D-3-PHOSPHOGLYCERATE DEHYDROGENASE (PHOSPHOGL 1psd( A) 1yba( D) true false 1.1.1.95  details
D-ALANINE 1ehi( A) 1ehi( B) true true 6.3.2.4  details
delta1-piperideine-2-carboxylate reductase 2cwf( A) 1wtj( B) true false 1.1.1.154  details
Dephospho-CoA kinase 1viy( C) 1vhl( A) false false 2.7.1.24  details
Dephospho-CoA kinase 1vhl( A) 1n3b( B) false false 2.7.1.24  details
Diamine acetyltransferase 1 2b58( A) 2b3u( A) true false 2.3.1.57  details
Diamine acetyltransferase 2 2bei( B) 2bei( A) true true 2.3.1.57  details
DIAMINOPIMELIC ACID DEHYDROGENASE 1f06( A) 1f06( B) true true 1.4.1.16  details
Dihydrodipicolinate reductase 1yl7( C) 1yl5( B) true false 1.3.1.26  details
Dihydrodipicolinate reductase 1yl5( B) 1yl7( D) true false 1.3.1.26  details
Dihydrodipicolinate reductase 1yl7( C) 1p9l( A) true true 1.3.1.26  details
diphosphate--fructose-6-phosphate 1-phosphotr 2f48( B) 2f48( A) true true 2.7.1.90  details
DIPHTHERIA TOXIN (DIMERIC) 1f0l( B) 1tox( B) true true 2.4.2.36  details
D-LACTATE DEHYDROGENASE 1j49( B) 1j4a( D) true true 1.1.1.28  details
DNA-directed RNA polymerase 1h38( A) 1s77( D) true true 2.7.7.6  details
enolase 1 1ebh( B) 1one( A) true true 4.2.1.11  details
Erythronate-4-phosphate dehydrogenase 2o4c( B) 2o4c( A) true true 1.1.1.290  details
farnesyl pyrophosphate synthase 1yhk( A) 1yhl( A) true true 2.5.1.10  details
Ferrochelatase 2hre( D) 2hrc( B) true true 4.99.1.1  details
Flagellum-specific ATP synthase 2dpy( B) 2dpy( A) false false 3.6.3.14  details
Folylpolyglutamate synthase 1jbw( A) 2gc5( A) true true 6.3.2.17  details
FUMARYLACETOACETATE HYDROLASE 2hzy( B) 1hyo( B) true false 3.7.1.2  details
GLGA GLYCOGEN SYNTHASE 2bis( B) 2bis( A) false true 2.4.1.21  details
Glucokinase 1q18( A) 1sz2( B) true true 2.7.1.2  details
glucokinase isoform 2 1v4s( A) 1v4t( A) true true 2.7.1.1  details
Gluconate kinase 1ko5( B) 1knq( A) false false 2.7.1.12  details
GLUCOSAMINE-FRUCTOSE-6-PHOSPHATE AMINOTRANSFE 2j6h( A) 1jxa( C) true true 2.6.1.16  details
GLUCOSE 6-PHOSPHATE DEHYDROGENASE 1dpg( B) 2dpg( ) false false 1.1.1.49  details
GLUTAMATE DEHYDROGENASE 1hwx( C) 1nr1( C) true true 1.4.1.3  details
GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTR 1ecc( B) 1ecf( B) true true 2.4.2.14  details
GLUTATHIONE S-TRANSFERASE 1xw5( B) 1hnb( A) true true 2.5.1.18  details
glutathione synthetase 1m0w( A) 1m0t( B) true true 6.3.2.3  details
Glyceraldehyde 3-phosphate dehydrogenase 2gd1( R) 1nq5( A) true true 1.2.1.12  details
Glycerol dehydrogenase 1jq5( A) 1jpu( A) true true 1.1.1.6  details
GLYCOGEN PHOSPHORYLASE B 1z8d( A) 1pyg( B) true true 2.4.1.1  details
Glycogen synthase 1 1rzu( B) 1rzu( A) true true 2.4.1.21  details
Glyoxylate reductase/hydroxypyruvate reductas 2h1s( C) 2gcg( B) true true 1.1.1.79  details
Guanylate kinase 2anb( A) 2f3t( C) true true 2.7.4.8  details
Guanylate kinase 2f3t( C) 2f3t( F) false true 2.7.4.8  details
GUANYLATE KINASE 1ex6( B) 1ex7( A) true true 2.7.4.8  details
GUANYLATE KINASE 2j41( A) 2j41( D) true true 2.7.4.8  details
Heat shock cognate 71 kDa protein 1hx1( A) 1kaz( ) true true 3.6.1.3  details
HEME OXYGENASE-1 1ix3( A) 1irm( C) true true 1.14.99.3  details
Hypothetical protein Rv1264/MT1302 1y11( A) 1y10( B) false true 4.6.1.1  details
HYPOXANTHINE GUANINE PHOSPHORIBOSYL-TRANSFERA 1bzy( C) 1z7g( C) true true 2.4.2.8  details
HYPOXANTHINE GUANINE PHOSPHORIBOSYL-TRANSFERA 1z7g( C) 1hmp( A) true false 2.4.2.8  details
INOSINE TRIPHOSPHATE PYROPHOSPHATASE 2car( A) 2j4e( D) true true 3.6.1.19  details
Inositol monophosphatase 2 2czh( A) 2czk( A) true true 3.1.3.25  details
Isocitrate dehydrogenase 1xkd( B) 1xkd( A) true true 1.1.1.42  details
Isocitrate dehydrogenase 1j1w( A) 1itw( D) true true 1.1.1.42  details
Isocitrate dehydrogenase [NADP] 1sjs( ) 1hj6( A) true true 1.1.1.42  details
Isocitrate dehydrogenase [NADP] cytoplasmic 1t09( A) 1t0l( D) true true 1.1.1.42  details
Ketopantoate reductase 1ks9( A) 2ofp( B) true true 1.1.1.169  details
Ketopantoate reductase 1ks9( A) 1yjq( A) false true 1.1.1.169  details
L-3-HYDROXYACYL-COA DEHYDROGENASE 1f0y( A) 1f17( B) true true 1.1.1.35  details
L-allo-threonine aldolase 2fm1( D) 1lw5( A) false false 4.1.2.5  details
L-allo-threonine aldolase 1lw5( A) 2fm1( B) false false 4.1.2.5  details
long chain fatty acid-CoA ligase 1ult( A) 1v25( B) true true 6.2.1.3  details
LYSINE-SENSITIVE ASPARTOKINASE 3 2j0w( A) 2j0x( A) true true 2.7.2.4  details
Maltose/maltodextrin import ATP-binding prote 1q1e( A) 2awn( C) false true 3.6.3.19  details
MALTOSE PHOSPHORYLASE 1h54( B) 1h54( A) true true 2.4.1.8  details
mannitol dehydrogenase 1lj8( A) 1m2w( A) true false 1.1.1.67  details
Methylene Tetrahydromethanopterin Dehydrogena 1lu9( A) 1lua( C) true false 1.5.1.5  details
Methyltransferase 1 2i2x( J) 2i2x( B) false false 2.1.1.90  details
MRNA CAPPING ENZYME 1cko( ) 1ckm( A) false true 2.7.7.50  details
MRNA CAPPING ENZYME 1cko( ) 1ckm( B) true true 2.7.7.50  details
mRNA capping enzyme alpha subunit 1p16( A) 1p16( B) false false 2.7.7.50  details
NAD-dependent alcohol dehydrogenase 1r37( A) 1jvb( A) true true 1.1.1.1  details
NAD-DEPENDENT MALIC ENZYME 1pj3( C) 1pjl( A) true true 1.1.1.39  1.1.1.38  details
NAD(P) transhydrogenase subunit alpha 1x14( B) 1x15( A) false false 1.6.1.2  details
NAD(P) transhydrogenase subunit alpha part 1 1u28( A) 1l7d( B) true false 1.6.1.2  1.6.1.1  details
NAGK PROTEIN 2ch6( D) 2ch6( B) true true 2.7.1.59  details
Nickel-binding periplasmic protein 2noo( A) 1zlq( B) true false 3.6.3.24  details
Nickel-binding periplasmic protein 2noo( A) 1uiu( A) true false 3.6.3.24  details
NICOTINAMIDE MONONUCLEOTIDE ADENYLYL TRANSFER 1kku( A) 1kqo( E) true true 2.7.7.1  details
NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE 1kam( B) 1kaq( A) true true 2.7.7.18  details
NITRIC OXIDE SYNTHASE 1noc( A) 1vaf( A) false true 1.14.13.39  details
Nitrogenase Molybdenum-Iron Protein alpha cha 1l5h( A) 1m1n( E) true true 1.18.6.1  details
Nucleoside diphosphate kinase II 1s59( F) 1s59( C) true true 2.7.4.6  details
OROTIDINE 5'-MONOPHOSPHATE DECARBOXYLASE 1eix( C) 1l2u( A) true true 4.1.1.23  details
Orotidine 5'-phosphate decarboxylase 2cze( A) 2czd( B) true true 4.1.1.23  details
PANTOATE--BETA-ALANINE LIGASE 1iho( B) 1iho( A) false false 6.3.2.1  details
PANTOTHENATE KINASE 1esm( B) 1esn( A) false false 2.7.1.33  details
PHENOL HYDROXYLASE 1pn0( A) 1pn0( D) true false 1.14.13.7  details
Phosophoribosylglycinamide formyltransferase 1meo( A) 1men( C) true true 2.1.2.2  details
Phosphate acetyltransferase 1qzt( B) 2af3( C) true false 2.3.1.8  details
Phospho-2-dehydro-3-deoxyheptonate aldolase 1rzm( B) 1vr6( A) false true 2.5.1.54  details
phosphoenolpyruvate carboxykinase [ATP] 1ytm( B) 1yvy( A) true true 4.1.1.49  details
Phosphoenolpyruvate carboxykinase [ATP] 1oen( ) 1os1( A) true true 4.1.1.49  details
phosphoglycerate dehydrogenase 1wwk( A) 1wwk( B) true true 1.1.1.95  details
phosphoglycerate kinase 1kf0( A) 1vjc( A) true false 2.7.2.3  details
PHOSPHOGLYCERATE KINASE 1qpg( ) 1fw8( A) false false 2.7.2.3  details
PHOSPHOSERINE PHOSPHATASE (PSP) 1l7o( B) 1l7p( B) true true 3.1.3.3  details
Poly(A) polymerase 2hhp( A) 1fa0( A) false false 2.7.7.19  details
Probable butyrate kinase 2 1saz( A) 1x9j( D) true false 2.7.2.7  details
PROTEIN (CATALASE HPII) 1ggk( C) 1gg9( A) false true 1.11.1.6  details
PROTEIN (DIAMINOPIMELATE EPIMERASE) 2gke( A) 1gqz( A) true true 5.1.1.7  details
PROTEIN (F1-ATPASE BETA CHAIN) 2jdi( E) 1h8e( E) true false 3.6.3.14  3.6.1.34  details
PROTEIN (F1-ATPASE BETA CHAIN) 2jdi( E) 1h8e( D) false true 3.6.3.14  3.6.1.34  details
PROTEIN (FERREDOXIN 1qfy( B) 1sm4( B) false false 1.18.1.2  details
PROTEIN (N5-CARBOXYAMINOIMIDAZOLE RIBONUCLEOT 1b6r( A) 1b6s( B) true true 4.1.1.21  details
PROTEIN (NUCLEOSIDE DIPHOSPHATE KINASE) 1pae( X) 1b4s( A) true true 2.7.4.6  details
PROTEIN (THYMIDYLATE SYNTHASE) 1b02( A) 1bkp( B) true true 2.1.1.45  details
PROTEIN (UREASE ALPHA SUBUNIT) 3ubp( C) 4ubp( C) false false 3.5.1.5  details
PROTEIN (URIDYLMONOPHOSPHATE/CYTIDYLMONOPHOSP 1uke( ) 1qf9( A) true true 2.7.4.14  details
Putative phosphoglycolate phosphatase 2hi0( A) 2hi0( B) true false 3.1.3.18  details
Pyranose oxidase 2igk( E) 2f6c( A) false true 1.1.3.10  details
Pyruvate kinase isozymes M1/M2 1a49( D) 1aqf( H) true true 2.7.1.40  details
pyruvate,orthophosphate dikinase 1vbg( A) 1vbh( A) false false 2.7.9.1  details
R-alcohol dehydrogenase 1zk3( C) 1zk4( A) true false 1.1.1.2  details
Riboflavin biosynthesis protein ribD 2d5n( B) 2d5n( A) false false 3.5.4.26  1.1.1.193  details
RIBOKINASE 1rka( A) 1rkd( ) true true 2.7.1.15  details
RNA uridylyl transferase 2ikf( B) 2ikf( A) true true 2.7.7.52  details
RuvB 1hqc( A) 1ixr( C) false true 3.6.1.3  details
S-adenosylmethionine synthetase isoform type- 2obv( A) 1qm4( A) true true 2.5.1.6  details
Sarcoplasmic/endoplasmic reticulum calcium AT 1wpg( C) 2eau( A) true false 3.6.3.8  details
Serine acetyltransferase 1sst( C) 1ssq( D) false false 2.3.1.30  details
SERINE/THREONINE-PROTEIN KINASE CHK2 2cn5( A) 2cn8( A) false false 2.7.11.1  details
SERYL-tRNA SYNTHETASE 1ses( A) 1ses( B) false true 6.1.1.11  details
shikimate 5-dehydrogenase 2d5c( A) 1wxd( B) true true 1.1.1.25  details
Succinyl-CoA ligase [GDP-forming] beta-chain, 1eud( B) 2fp4( B) true true 6.2.1.4  details
Succinyl-CoA ligase [GDP-forming] beta-chain, 2fp4( B) 2fpi( B) false true 6.2.1.4  details
Sucrose-Phosphatase 1s2o( A) 1tj5( A) true true 3.1.3.24  details
sulfate adenylyltransferase 1i2d( C) 1m8p( A) false true 2.7.7.4  details
THREONINE SYNTHASE 1v7c( C) 1uin( A) true false 4.2.3.1  details
THYMIDYLATE SYNTHASE 1i00( B) 1ju6( D) true false 2.1.1.45  details
THYMIDYLATE SYNTHASE 1ev8( A) 2g8o( A) true true 2.1.1.45  details
Trichodiene synthase 1yyq( A) 1yyq( B) true true 4.2.3.6  details
Triosephosphate isomerase 1tim( B) 1ssg( A) true true 5.3.1.1  details
tRNA (Guanine-N(1)-)-methyltransferase 1uaj( A) 1ual( A) false false 2.1.1.31  details
TRYPTOPHANASE 2oqx( A) 2c44( C) false true 4.1.99.1  details
TRYPTOPHAN SYNTHASE 2tys( B) 1qoq( B) true false 4.2.1.20  details
Tryptophanyl-tRNA synthetase 1mau( A) 1maw( B) true true 6.1.1.2  details
Tryptophanyl-tRNA synthetase 1mau( A) 1i6m( A) true false 6.1.1.2  details
Type II restriction enzyme PvuII 1ni0( B) 1h56( A) false false 3.1.21.4  details
tyrosyl-tRNA synthetase 1n3l( A) 1q11( A) true true 6.1.1.1  details
TYROSYL-TRNA SYNTHETASE 1h3e( A) 1h3f( B) false true 6.1.1.1  details
UDP-glucose 4-epimerase 2udp( A) 1lrk( A) true false 5.1.3.2  details
UDP-N-ACETYLGLUCOSAMINE-1-PHOSPHATE URIDYLTRA 1hm0( A) 1hm9( A) true true 2.7.7.23  details
UDP-N-acetylglucosamine 2-epimerase 1vgv( D) 1vgv( B) true true 5.1.3.14  details
UDP-N-ACETYLGLUCOSAMINE PYROPHOSPHORYLASE 1fwy( B) 1fxj( A) true true 2.7.7.23  details
UDP-N-ACETYLMURAMATE-L-ALANINE LIGASE 1p3d( A) 1gqq( B) true true 6.3.2.8  details
UDP-N-ACETYLMURAMOYL-L-ALANINE 1e0d( A) 4uag( A) true true 6.3.2.9  details
UDP-N-ACETYLMURAMOYL-L-ALANINE 1eeh( A) 1e0d( A) false true 6.3.2.9  details
Undecaprenyl pyrophosphate synthetase 1x09( A) 1jp3( B) true true 2.5.1.31  details
URACIL-DNA GLYCOSYLASE 1flz( A) 1eui( A) true true 3.2.2.3  details
URIDINE DIPHOSPHO-N-ACETYLENOLPYRUVYLGLUCOSAM 1mbt( ) 1uxy( ) true true 1.1.1.158  details
UTP-glucose-1-phosphate uridylyltransferase 2 2oef( A) 2oeg( A) true true 2.7.7.9  details
Xanthine phosphoribosyltransferase 1y0b( A) 2fxv( A) true false 2.4.2.22  details

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